Cell Stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells
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| Опубліковано в:: | PLoS One vol. 7, no. 10 (Oct 2012), p. e46609 |
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| Автор: | |
| Інші автори: | , , , , |
| Опубліковано: |
Public Library of Science
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| Предмети: | |
| Онлайн доступ: | Citation/Abstract Full Text Full Text - PDF |
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| 001 | 1345197324 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 1932-6203 | ||
| 024 | 7 | |a 10.1371/journal.pone.0046609 |2 doi | |
| 035 | |a 1345197324 | ||
| 045 | 2 | |b d20121001 |b d20121031 | |
| 084 | |a 174835 |2 nlm | ||
| 100 | 1 | |a Xu, Wenwei | |
| 245 | 1 | |a Cell Stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells | |
| 260 | |b Public Library of Science |c Oct 2012 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a The metastatic potential of cells is an important parameter in the design of optimal strategies for the personalized treatment of cancer. Using atomic force microscopy (AFM), we show, consistent with previous studies conducted in other types of epithelial cancer, that ovarian cancer cells are generally softer and display lower intrinsic variability in cell stiffness than non-malignant ovarian epithelial cells. A detailed examination of highly invasive ovarian cancer cells (HEY A8) relative to their less invasive parental cells (HEY), demonstrates that deformability is also an accurate biomarker of metastatic potential. Comparative gene expression analyses indicate that the reduced stiffness of highly metastatic HEY A8 cells is associated with actin cytoskeleton remodeling and microscopic examination of actin fiber structure in these cell lines is consistent with this prediction. Our results indicate that cell stiffness may be a useful biomarker to evaluate the relative metastatic potential of ovarian and perhaps other types of cancer cells. | |
| 651 | 4 | |a Georgia | |
| 651 | 4 | |a Atlanta Georgia | |
| 651 | 4 | |a United States--US | |
| 653 | |a Physiology | ||
| 653 | |a Mechanical properties | ||
| 653 | |a Formability | ||
| 653 | |a Metastasis | ||
| 653 | |a Atomic structure | ||
| 653 | |a Disease | ||
| 653 | |a Stiffness | ||
| 653 | |a Deformability | ||
| 653 | |a Cytoskeleton | ||
| 653 | |a Atomic force microscopy | ||
| 653 | |a Biomedical engineering | ||
| 653 | |a Biology | ||
| 653 | |a Metastases | ||
| 653 | |a Kinases | ||
| 653 | |a Mechanical engineering | ||
| 653 | |a Ovarian cancer | ||
| 653 | |a Signal transduction | ||
| 653 | |a Gene expression | ||
| 653 | |a Social | ||
| 653 | |a Environmental | ||
| 653 | |a Blood diseases | ||
| 653 | |a Actin | ||
| 653 | |a Antibiotics | ||
| 653 | |a Cancer | ||
| 653 | |a Deformation | ||
| 653 | |a Microscopy | ||
| 653 | |a Medical research | ||
| 653 | |a Biomarkers | ||
| 653 | |a Epithelial cells | ||
| 653 | |a Design parameters | ||
| 653 | |a Invasiveness | ||
| 700 | 1 | |a Mezencev, Roman | |
| 700 | 1 | |a Kim, Byungkyu | |
| 700 | 1 | |a Wang, Lijuan | |
| 700 | 1 | |a McDonald, John | |
| 700 | 1 | |a Sulchek, Todd | |
| 773 | 0 | |t PLoS One |g vol. 7, no. 10 (Oct 2012), p. e46609 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/1345197324/abstract/embedded/ZKJTFFSVAI7CB62C?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text |u https://www.proquest.com/docview/1345197324/fulltext/embedded/ZKJTFFSVAI7CB62C?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/1345197324/fulltextPDF/embedded/ZKJTFFSVAI7CB62C?source=fedsrch |