DNA Tetrominoes: The Construction of DNA Nanostructures Using Self-Organised Heterogeneous Deoxyribonucleic Acids Shapes
में बचाया:
| में प्रकाशित: | PLoS One vol. 10, no. 8 (Aug 2015), p. e0134520 |
|---|---|
| मुख्य लेखक: | |
| अन्य लेखक: | , , |
| प्रकाशित: |
Public Library of Science
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| विषय: | |
| ऑनलाइन पहुंच: | Citation/Abstract Full Text Full Text - PDF |
| टैग: |
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MARC
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| 022 | |a 1932-6203 | ||
| 024 | 7 | |a 10.1371/journal.pone.0134520 |2 doi | |
| 035 | |a 1702843331 | ||
| 045 | 2 | |b d20150801 |b d20150831 | |
| 084 | |a 174835 |2 nlm | ||
| 100 | 1 | |a Hui San Ong | |
| 245 | 1 | |a DNA Tetrominoes: The Construction of DNA Nanostructures Using Self-Organised Heterogeneous Deoxyribonucleic Acids Shapes | |
| 260 | |b Public Library of Science |c Aug 2015 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a The unique programmability of nucleic acids offers alternative in constructing excitable and functional nanostructures. This work introduces an autonomous protocol to construct DNA Tetris shapes (L-Shape, B-Shape, T-Shape and I-Shape) using modular DNA blocks. The protocol exploits the rich number of sequence combinations available from the nucleic acid alphabets, thus allowing for diversity to be applied in designing various DNA nanostructures. Instead of a deterministic set of sequences corresponding to a particular design, the protocol promotes a large pool of DNA shapes that can assemble to conform to any desired structures. By utilising evolutionary programming in the design stage, DNA blocks are subjected to processes such as sequence insertion, deletion and base shifting in order to enrich the diversity of the resulting shapes based on a set of cascading filters. The optimisation algorithm allows mutation to be exerted indefinitely on the candidate sequences until these sequences complied with all the four fitness criteria. Generated candidates from the protocol are in agreement with the filter cascades and thermodynamic simulation. Further validation using gel electrophoresis indicated the formation of the designed shapes. Thus, supporting the plausibility of constructing DNA nanostructures in a more hierarchical, modular, and interchangeable manner. | |
| 610 | 4 | |a Universiti Malaya-Kuala Lumpur Malaysia | |
| 651 | 4 | |a Malaysia | |
| 651 | 4 | |a Kuala Lumpur Malaysia | |
| 653 | |a Gel electrophoresis | ||
| 653 | |a Computer science | ||
| 653 | |a Gene deletion | ||
| 653 | |a Fitness | ||
| 653 | |a Symmetry | ||
| 653 | |a Structural engineering | ||
| 653 | |a Nucleic acids | ||
| 653 | |a Nanotechnology | ||
| 653 | |a Nucleotide sequence | ||
| 653 | |a Cascades | ||
| 653 | |a Evolutionary algorithms | ||
| 653 | |a Computer simulation | ||
| 653 | |a Insertion | ||
| 653 | |a Economic | ||
| 653 | |a Nanostructure | ||
| 653 | |a Shape optimization | ||
| 653 | |a Gene sequencing | ||
| 653 | |a Deoxyribonucleic acid--DNA | ||
| 653 | |a Design | ||
| 653 | |a Electrophoresis | ||
| 653 | |a Information technology | ||
| 653 | |a Modular construction | ||
| 653 | |a Mutation | ||
| 653 | |a Reproductive fitness | ||
| 653 | |a Artificial intelligence | ||
| 653 | |a Laboratories | ||
| 700 | 1 | |a Rahim, Mohd Syafiq | |
| 700 | 1 | |a Firdaus-Raih, Mohd | |
| 700 | 1 | |a Ramlan, Effirul Ikhwan | |
| 773 | 0 | |t PLoS One |g vol. 10, no. 8 (Aug 2015), p. e0134520 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/1702843331/abstract/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text |u https://www.proquest.com/docview/1702843331/fulltext/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/1702843331/fulltextPDF/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |