The relative level of choline: the value in the preoperative evaluation of cerebral glioma grading and the correlation with cell proliferation in gliomas
Sábháilte in:
| Foilsithe in: | Chinese Journal of Magnetic Resonance Imaging vol. 6, no. 9 (0, 2015) |
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| Príomhchruthaitheoir: | |
| Rannpháirtithe: | , , , , , , |
| Foilsithe / Cruthaithe: |
Chinese Hospitals Press
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| Ábhair: | |
| Rochtain ar líne: | Citation/Abstract |
| Clibeanna: |
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
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| Achoimre: | Objective: To investigate the value of the relative level of choline measured by proton magnetic resonance spectroscopy in the preoperative evaluation of cerebral gliomas grading and the correlation with cell proliferation in gliomas. Materials and Methods: Fifty-eight patients with cerebral gliomas confirmed by histopathology were collected. All patients were performed with 1H-MRS. On the basis of the histopathological diagnosis, the patients were classified into three groups: grade I-II (low-grade), 25 cases, grade III, 19, grade IV, 14. Those whose grades were III or IV were classified into high-grade gliomas group that included 33 cases. The regions of the maximum Cho/Cr value in solid portion of the tumors and the contralateral normal white matter were selected as regions of interest(ROI). The values of Cho/NAA, Cho/Cr, relative Cho/NAA(r Cho/NAA) and relative Cho/Cr(r Cho/Cr) of ROIs were obtained. Ki-67 grading was defined as follow: labeling index(LI) <5% is negative(-), 5%[< or =]LI<25% is weakly positive(+), 25%[< or =]LI<50% is positive(++), and LI > or =50% is strongly positive(+++). The differences of parameters of the relative level of choline among three groups were analyzed, if the parameters of the relative level of choline had no significant difference between grade III and IV gliomas, we compared the difference between low-grade and high-grade gliomas. The optimum diagnostic thresholds of the parameters were achieved by using receiver operating characteristic curve(ROC), and we calculated the area under the curve(AUC), sensitivity, specificity and accuracy. The correlation between Ki-67 grading and glioma grading, and the correlation between Ki-67 grading and parameters of the relative level of choline were analyzed. Result: The Cho/NAA, Cho/Cr, r Cho/NAA and r Cho/Cr values of solid portions of tumor of grade III and grade IV gliomas were significantly higher than that of grade I-II gliomas(P<0.05), however, there was no significant difference between grade III and grade IV gliomas(P>0.05). There were significant differences between low-grade and high-grade gliomas(P<0.05). In the parameters of the relative level of choline to differentiate high-grade gliomas from low-grade gliomas, the accuracy of Cho/NAA was the highest, which equaled to 81.0%, and the threshold was 3.04. The AUC of r Cho/Cr was maximum, which was 0.823, and the threshold and accuracy were 2.70 and 77.6%, respectively. There was significant difference between different grade gliomas in Ki-67 grading, and there was a positive correlation between Ki-67 grading and gliomas grading(r=0.741, P<0.05). Cho/NAA, Cho/Cr and r Cho/Cr had positive correlation with Ki-67 grading(r were 0.313, 0.444 and 0.336, respectively, P<0.05). Conclusions: The relative level of choline is a great indicator that can indicate the state of gliomas cell proliferation and evaluate the level of malignant, it is helpful for classification of cerebral gliomas grading before operation. |
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| ISSN: | 1674-8034 |
| Foinse: | Engineering Index |