^sup 99m^Tc-Sestamibi Brain SPECT After Chemoradiotherapy Is Prognostic of Survival in Patients with High-Grade Glioma

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Detalles Bibliográficos
Publicado en:	The Journal of Nuclear Medicine vol. 45, no. 3 (Mar 2004), p. 409-413
Autor principal:	Beauchesne, Patrick
Otros Autores:	Pedeux, Remy, Boniol, Mathieu, Soler, Claude
Publicado:	Society of Nuclear Medicine
Materias:	Brain > radionuclide imaging Brain Neoplasms > diagnosis Brain Neoplasms > mortality Brain Neoplasms > radionuclide imaging Brain Neoplasms > radiotherapy Disease-Free Survival Female Glioma > diagnosis Glioma > mortality Glioma > radionuclide imaging Glioma > radiotherapy Humans Male Middle Aged Prognosis Radiopharmaceuticals > diagnostic use Reproducibility of Results Risk Assessment > methods Sensitivity & Specificity Survival Rate Technetium Tc 99m Sestamibi > diagnostic use Tomography, Emission-Computed, Single-Photon > methods Treatment Outcome United States > epidemiology
Acceso en línea:	Citation/Abstract Full Text + Graphics Full Text - PDF
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Descripción
Resumen:	This prospective clinical study used (99m)Tc-sestamibi (MIBI) brain SPECT to assess residual tumor volume and determine whether it would be prognostic of survival at the end of cranial irradiation in patients with malignant glioma. Fifty-seven patients with supratentorial malignant glioma were included in this clinical trial. Tomoscintigraphy was performed 4 h after an intravenous injection of MIBI (1,110 MBq). The images were obtained from a dual-head gamma-camera using fanbeam collimators. Transverse, coronal, and sagittal views were reconstructed. Metabolic tumor volume (MTV), using an ellipsoid model, was calculated from the 3 slices. The first posttherapeutic neuroradiologic evaluation was performed at the end of each patient's radiation therapy. (99m)Tc-MIBI brain SPECT performed at the end of cranial irradiation provided data that allowed the identification of residual tumor and could be used to accurately predict survival of malignant glioma patients, taking into account the established prognostic factors. Patients with an MTV < 32 cm(3) had a median survival of 358 d, as opposed to 238 d in patients with an MTV >or= 32 cm(3) (P = 0.05). Moreover, half of CT scans performed at the same time were considered to show doubtful or only suggestive findings. No diagnosis of tumor progression or inflammatory changes was possible. (99m)Tc-MIBI brain SPECT may help in establishing the prognosis of glioma patients at the end of radiation therapy. Consequently, the management of patients can be adapted. These new data should be considered in the design of future clinical studies of malignant glioma patients as a way to quickly assess the efficiency of therapies.
ISSN:	0161-5505 1535-5667 0022-3123 0097-9031 0097-9058
Fuente:	Science Database