Purkinje cell number-correlated cerebrocerebellar circuit anomaly in the valproate model of autism
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| 發表在: | Scientific Reports (Nature Publisher Group) vol. 9 (Jun 2019), p. 1 |
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| 主要作者: | |
| 其他作者: | , , , , , , , , , , , , |
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Nature Publishing Group
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| 在線閱讀: | Citation/Abstract Full Text - PDF |
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| 024 | 7 | |a 10.1038/s41598-019-45667-1 |2 doi | |
| 035 | |a 2246933422 | ||
| 045 | 2 | |b d20190601 |b d20190630 | |
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| 100 | 1 | |a Spisák, Tamás |u Pharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary; Department of Neurology, University Hospital Essen, Essen, Germany | |
| 245 | 1 | |a Purkinje cell number-correlated cerebrocerebellar circuit anomaly in the valproate model of autism | |
| 260 | |b Nature Publishing Group |c Jun 2019 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a While cerebellar alterations may play a crucial role in the development of core autism spectrum disorder (ASD) symptoms, their pathophysiology on the function of cerebrocerebellar circuit loops is largely unknown. We combined multimodal MRI (9.4 T) brain assessment of the prenatal rat valproate (VPA) model and correlated immunohistological analysis of the cerebellar Purkinje cell number to address this question. We hypothesized that a suitable functional MRI (fMRI) paradigm might show some altered activity related to disrupted cerebrocerebellar information processing. Two doses of maternal VPA (400 and 600 mg/kg, s.c.) were used. The higher VPA dose induced 3% smaller whole brain volume, the lower dose induced 2% smaller whole brain volume and additionally a focal gray matter density decrease in the cerebellum and brainstem. Increased cortical BOLD responses to whisker stimulation were detected in both VPA groups, but it was more pronounced and extended to cerebellar regions in the 400 mg/kg VPA group. Immunohistological analysis revealed a decreased number of Purkinje cells in both VPA groups. In a detailed analysis, we revealed that the Purkinje cell number interacts with the cerebral BOLD response distinctively in the two VPA groups that highlights atypical function of the cerebrocerebellar circuit loops with potential translational value as an ASD biomarker. | |
| 653 | |a Autism | ||
| 653 | |a Valproic acid | ||
| 653 | |a Cortex | ||
| 653 | |a Information processing | ||
| 653 | |a Substantia grisea | ||
| 653 | |a Functional magnetic resonance imaging | ||
| 653 | |a Cerebellum | ||
| 653 | |a Brain stem | ||
| 653 | |a Purkinje cells | ||
| 653 | |a Brain mapping | ||
| 653 | |a Cell number | ||
| 653 | |a Environmental | ||
| 700 | 1 | |a Román, Viktor |u Pharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary | |
| 700 | 1 | |a Papp, Edit |u Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary | |
| 700 | 1 | |a Kedves, Rita |u Pharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary | |
| 700 | 1 | |a Sághy, Katalin |u Pharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary | |
| 700 | 1 | |a Csölle, Cecília Katalin |u Pharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary | |
| 700 | 1 | |a Varga, Anita |u Pharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary | |
| 700 | 1 | |a Gajári, Dávid |u Pharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary | |
| 700 | 1 | |a Nyitrai, Gabriella |u Pharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary | |
| 700 | 1 | |a Spisák, Zsófia |u Pharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary | |
| 700 | 1 | |a Zsigmond, Tamás Kincses |u Pharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary; Department of Neurology, University of Szeged, Szeged, Hungary | |
| 700 | 1 | |a Lévay, György |u Pharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary | |
| 700 | 1 | |a Lendvai, Balázs |u Pharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary | |
| 700 | 1 | |a Czurkó, András |u Pharmacology and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary | |
| 773 | 0 | |t Scientific Reports (Nature Publisher Group) |g vol. 9 (Jun 2019), p. 1 | |
| 786 | 0 | |d ProQuest |t Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/2246933422/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/2246933422/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |