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Ki67 index in intrinsic breast cancer subtypes and its association with prognostic parameters

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Publicado en:BMC Research Notes vol. 12 (2019), p. n/a
Autor principal: Atif Ali Hashmi
Otros Autores: Kashif Ali Hashmi, Muhammad Irfan, Saadia Mehmood Khan, Edhi, Muhammad Muzzammil, Javaria Parwez Ali, Shumaila Kanwal Hashmi, Huda Asif, Faridi, Naveen, Khan, Amir
Publicado:
Springer Nature B.V.
Materias:
Pakistan
Karachi Pakistan
Biomarkers
Breast cancer
Flow cytometry
Gene amplification
Studies
Cancer therapies
Chemotherapy
Biopsy
Acceso en línea:Citation/Abstract
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Resumen:Objectives Ki67 is the most commonly used marker to evaluate proliferative index in breast cancer, however no cutoff values have been clearly defined for high ki67 index. Cancer management should be according to loco-regional profile; therefore, we aimed to determine ki67 index in 1951 cases of intrinsic breast cancer subtypes and its association with other prognostic parameters in our set up. Results Triple negative breast cancers showed highest ki67 index (mean 50.9 ± 23.7%) followed by Her2neu (mean 42.6 ± 21.6%) and luminal B cancers (mean 34.9 ± 20.05%). Metaplastic and medullary breast cancers significantly showed higher ki67 index as compared to ductal carcinoma, NOS. No significant association of ki67 index was noted with any of the histologic parameters in different subtypes of breast cancer expect for tumor grade. Although, ki67 index is a valuable biomarker in breast cancer, however no independent prognostic significance of ki67 could be established in our study.
ISSN:1756-0500
DOI:10.1186/s13104-019-4653-x
Fuente:Health & Medical Collection