Patterns of viral pathogens causing upper respiratory tract infections among symptomatic children in Mwanza, Tanzania
Guardado en:
| Publicado en: | Scientific Reports (Nature Publisher Group) vol. 10, no. 1 (2020) |
|---|---|
| Autor principal: | |
| Otros Autores: | , , , , , , , , , , |
| Publicado: |
Nature Publishing Group
|
| Materias: | |
| Acceso en línea: | Citation/Abstract Full Text - PDF |
| Etiquetas: |
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
MARC
| LEADER | 00000nab a2200000uu 4500 | ||
|---|---|---|---|
| 001 | 2471525819 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2045-2322 | ||
| 024 | 7 | |a 10.1038/s41598-020-74555-2 |2 doi | |
| 035 | |a 2471525819 | ||
| 045 | 2 | |b d20200101 |b d20201231 | |
| 084 | |a 274855 |2 nlm | ||
| 100 | 1 | |a Kwiyolecha, Elizabeth |u Catholic University of Health and Allied Sciences, Department of Pediatrics & Child Health, Mwanza, Tanzania (GRID:grid.411961.a) (ISNI:0000 0004 0451 3858) | |
| 245 | 1 | |a Patterns of viral pathogens causing upper respiratory tract infections among symptomatic children in Mwanza, Tanzania | |
| 260 | |b Nature Publishing Group |c 2020 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Upper-respiratory tract infections (URTI) are the leading causes of childhood morbidities. This study investigated etiologies and patterns of URTI among children in Mwanza, Tanzania. A cross-sectional study involving 339 children was conducted between October-2017 and February-2018. Children with features suggestive of URTI such as nasal congestion, dry cough, painful swallowing and nasal discharge with/without fever were enrolled. Pathogens were detected from nasopharyngeal and ear-swabs by multiplex-PCR and culture respectively. Full blood count and C-reactive protein analysis were also done. The median age was 16 (IQR: 8–34) months. Majority (82.3%) had fever and nasal-congestion (65.5%). Rhinitis (55.9%) was the commonest diagnosis followed by pharyngitis (19.5%). Viruses were isolated in 46% of children, the commonest being Rhinoviruses (23.9%). Nineteen percent of children had more than 2 viruses; Rhinovirus and Enterovirus being the commonest combination. The commonest bacteria isolated from ears were Staphylococcus aureus and Pseudomonas aeruginosa. Children with viral pathogens had significantly right shift of lymphocytes (73%—sensitivity). Majority (257/339) of children were symptoms free on eighth day. Viruses are the commonest cause of URTI with Rhinitis being the common diagnosis. Rapid diagnostic assays for URTI pathogens are urgently needed in low-income countries to reduce unnecessary antibiotic prescriptions which is associated with antibiotic resistance. | |
| 651 | 4 | |a Tanzania | |
| 653 | |a Pharyngitis | ||
| 653 | |a Respiration | ||
| 653 | |a Pathogens | ||
| 653 | |a Fever | ||
| 653 | |a Children | ||
| 653 | |a Cough | ||
| 653 | |a Antibiotics | ||
| 653 | |a Rhinitis | ||
| 653 | |a Lymphocytes | ||
| 653 | |a Respiratory tract diseases | ||
| 653 | |a Viruses | ||
| 653 | |a Antibiotic resistance | ||
| 653 | |a Ear | ||
| 653 | |a Diagnosis | ||
| 653 | |a C-reactive protein | ||
| 653 | |a Rhinovirus | ||
| 653 | |a Respiratory tract infection | ||
| 653 | |a Low income areas | ||
| 653 | |a Respiratory tract | ||
| 653 | |a Drug resistance | ||
| 653 | |a Social | ||
| 700 | 1 | |a Groendahl Britta |u University Medical Center of the Johannes Gutenberg University Mainz, Department of Pediatrics, Mainz, Germany (GRID:grid.410607.4) | |
| 700 | 1 | |a Okamo Bernard |u Catholic University of Health and Allied Sciences, Department of Biochemistry and Molecular Biology, Weill Bugando School of Medicine, Mwanza, Tanzania (GRID:grid.411961.a) (ISNI:0000 0004 0451 3858) | |
| 700 | 1 | |a Kayange Neema |u Catholic University of Health and Allied Sciences, Department of Pediatrics & Child Health, Mwanza, Tanzania (GRID:grid.411961.a) (ISNI:0000 0004 0451 3858) | |
| 700 | 1 | |a Manyama Festo |u Catholic University of Health and Allied Sciences, Department of Pediatrics & Child Health, Mwanza, Tanzania (GRID:grid.411961.a) (ISNI:0000 0004 0451 3858) | |
| 700 | 1 | |a Kidenya, Benson R |u Catholic University of Health and Allied Sciences, Department of Biochemistry and Molecular Biology, Weill Bugando School of Medicine, Mwanza, Tanzania (GRID:grid.411961.a) (ISNI:0000 0004 0451 3858) | |
| 700 | 1 | |a Mahamba, Dina C |u Catholic University of Health and Allied Sciences, Department of Pediatrics & Child Health, Mwanza, Tanzania (GRID:grid.411961.a) (ISNI:0000 0004 0451 3858) | |
| 700 | 1 | |a Msanga, Delfina R |u Catholic University of Health and Allied Sciences, Department of Pediatrics & Child Health, Mwanza, Tanzania (GRID:grid.411961.a) (ISNI:0000 0004 0451 3858) | |
| 700 | 1 | |a Gehring, Stephan |u University Medical Center of the Johannes Gutenberg University Mainz, Department of Pediatrics, Mainz, Germany (GRID:grid.410607.4) | |
| 700 | 1 | |a Mtebe, Majigo |u Muhimbili University of Health and Allied Sciences, Department of Microbiology and Immunology, Dar es Salaam, Tanzania (GRID:grid.25867.3e) (ISNI:0000 0001 1481 7466) | |
| 700 | 1 | |a Mshana, Stephen E |u Catholic University of Health and Allied Sciences, Department of Microbiology and Immunology, Weill Bugando School of Medicine, Mwanza, Tanzania (GRID:grid.411961.a) (ISNI:0000 0004 0451 3858) | |
| 700 | 1 | |a Mirambo, Mariam M |u Catholic University of Health and Allied Sciences, Department of Microbiology and Immunology, Weill Bugando School of Medicine, Mwanza, Tanzania (GRID:grid.411961.a) (ISNI:0000 0004 0451 3858) | |
| 773 | 0 | |t Scientific Reports (Nature Publisher Group) |g vol. 10, no. 1 (2020) | |
| 786 | 0 | |d ProQuest |t Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/2471525819/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/2471525819/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |