Pheno-Endotyping Antrochoanal Nasal Polyposis
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| Publicat a: | Current Allergy and Asthma Reports vol. 23, no. 3 (Mar 2023), p. 165 |
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| Autor principal: | |
| Altres autors: | , , |
| Publicat: |
Springer Nature B.V.
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| Matèries: | |
| Accés en línia: | Citation/Abstract Full Text - PDF |
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| Resum: | Purpose of ReviewAntrochoanal polyps (ACPs) are benign polypoid lesions arising from the inner wall of the maxillary sinus and extending into the choana. Although the diagnosis and treatment strategies of ACP have changed since this entity was first described, the underlying pathogenic mechanism of APC is poorly understood. This article reviews the current knowledge of the etiology, inflammatory parameters, and microscopic findings of ACP.Recent FindingsThe inflammatory pattern of ACP appears to center around a neutrophilic inflammation T1-dominant endotype. Apart from the inflammatory component of ACP, at the microscopic level, the presence of tissue remodeling, mostly fibrin deposition and edema, and cysts in the epithelium and lamina propria has been described. Although the origin of this T1-dominant endotype immune response of ACPs is not entirely clear, it could be related to a lymphatic obstruction mechanism.SummaryThis review serves to define a phenotype of ACP with potential endotypes based on the characteristics of the inflammatory parameters, microscopic findings, and hypotheses about the pathogenesis of ACP. |
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| ISSN: | 1529-7322 1534-6315 |
| DOI: | 10.1007/s11882-023-01066-1 |
| Font: | Health & Medical Collection |