Diabetes Intervention Accentuating Diet and Enhancing Metabolism (DIADEM-I): a randomised controlled trial to examine the impact of an intensive lifestyle intervention consisting of a low-energy diet and physical activity on body weight and metabolism in early type 2 diabetes mellitus: study protocol for a randomized controlled trial
I tiakina i:
| I whakaputaina i: | Trials vol. 19, no. 1 (Dec 2018), p. 284 |
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| Kaituhi matua: | |
| Ētahi atu kaituhi: | , , , , , , , , , , , , , , , , , , , , , , , , , |
| I whakaputaina: |
Springer Nature B.V.
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| Ngā marau: | |
| Urunga tuihono: | Citation/Abstract Full Text Full Text - PDF |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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MARC
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| 001 | 2795256539 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 1745-6215 | ||
| 022 | |a 1468-6708 | ||
| 022 | |a 1468-6694 | ||
| 024 | 7 | |a 10.1186/s13063-018-2660-1 |2 doi | |
| 035 | |a 2795256539 | ||
| 045 | 2 | |b d20181201 |b d20181231 | |
| 084 | |a 58363 |2 nlm | ||
| 100 | 1 | |a Taheri, Shahrad |u Department of Medicine, Weill Cornell Medicine – Qatar, Doha, Qatar; Weill Cornell Medicine – New York, Joan and Sanford I. Weill Department of Medicine, New York, USA (GRID:grid.5386.8) (ISNI:000000041936877X); Clinical Research Core, Weill Cornell Medicine – Qatar, Doha, Qatar (GRID:grid.5386.8); Qatar Metabolic Institute (QMI), Department of Medicine, Hamad Medical Corporation, Doha, Qatar (GRID:grid.413548.f) (ISNI:0000 0004 0571 546X); Weill Cornell Medicine – Qatar, Qatar Foundation – Education City, Doha, Qatar (GRID:grid.413548.f) | |
| 245 | 1 | |a Diabetes Intervention Accentuating Diet and Enhancing Metabolism (DIADEM-I): a randomised controlled trial to examine the impact of an intensive lifestyle intervention consisting of a low-energy diet and physical activity on body weight and metabolism in early type 2 diabetes mellitus: study protocol for a randomized controlled trial | |
| 260 | |b Springer Nature B.V. |c Dec 2018 | ||
| 513 | |a Evidence Based Healthcare Journal Article | ||
| 520 | 3 | |a BackgroundType 2 diabetes mellitus (T2DM) and obesity are syndemic and will have a significant impact on affected individuals and healthcare services worldwide. Evidence shows that T2DM remission can be achieved with significant weight loss in those who are younger with early diabetes and requiring fewer medications for glycaemic control. DIADEM-I aims to examine the impact of an intensive lifestyle intervention (ILI) using a low-energy diet (LED) meal replacement approach combined with physical activity in younger individuals with early T2DM.MethodsThe planned study is an ongoing, non-blinded, pragmatic, randomised controlled, parallel-group trial examining the impact of an LED-based ILI on body weight and diabetes remission in younger (18–50 years) T2DM individuals with early diabetes (≤ 3-year duration). The ILI will be compared to usual medical care (UMC). The primary outcome will be weight loss at 12 months. Other key outcomes of interest include diabetes remission, glycaemic control, diabetes complications, cardiovascular health, physical activity, mental health, and quality of life. It is planned for the study to include 138 subjects for assessment of the primary outcome. Safety will be assessed throughout.DiscussionIf DIADEM-I demonstrates a clinically significant effect for younger individuals with early T2DM, it will inform clinical guidelines and services of the future for management of T2DM.Trial registrationISRCTN: <ext-link xlink:href="https://doi.org/10.1186/ISRCTN20754766" ext-link-type="url">ISRCTN20754766</ext-link> (date assigned: 7 June 2017); ClinicalTrials.gov, ID: <ext-link xlink:href="https://clinicaltrials.gov/ct2/show/NCT03225339" ext-link-type="url">NCT03225339</ext-link> Registered on 26 June 2017. | |
| 651 | 4 | |a United Kingdom--UK | |
| 653 | |a Exercise | ||
| 653 | |a Diabetes | ||
| 653 | |a Physical fitness | ||
| 653 | |a Body mass index | ||
| 653 | |a Mortality | ||
| 653 | |a Intervention | ||
| 653 | |a Diet | ||
| 653 | |a Remission (Medicine) | ||
| 653 | |a Energy | ||
| 653 | |a Metabolism | ||
| 653 | |a Insulin | ||
| 653 | |a Aerobics | ||
| 653 | |a Gastrointestinal surgery | ||
| 653 | |a Age | ||
| 653 | |a Weight control | ||
| 653 | |a Liver | ||
| 653 | |a Blood pressure | ||
| 653 | |a Hypertension | ||
| 653 | |a Obesity | ||
| 653 | |a Cardiovascular disease | ||
| 653 | |a Primary care | ||
| 653 | |a Strength training | ||
| 653 | |a Feasibility studies | ||
| 653 | |a Systematic review | ||
| 653 | |a Lifestyles | ||
| 653 | |a Clinical practice guidelines | ||
| 700 | 1 | |a Chagoury, Odette |u Department of Medicine, Weill Cornell Medicine – Qatar, Doha, Qatar (GRID:grid.413548.f); Weill Cornell Medicine – New York, Joan and Sanford I. Weill Department of Medicine, New York, USA (GRID:grid.5386.8) (ISNI:000000041936877X); Clinical Research Core, Weill Cornell Medicine – Qatar, Doha, Qatar (GRID:grid.5386.8) | |
| 700 | 1 | |a Zaghloul, Hadeel |u Department of Medicine, Weill Cornell Medicine – Qatar, Doha, Qatar (GRID:grid.5386.8); Weill Cornell Medicine – New York, Joan and Sanford I. Weill Department of Medicine, New York, USA (GRID:grid.5386.8) (ISNI:000000041936877X); Clinical Research Core, Weill Cornell Medicine – Qatar, Doha, Qatar (GRID:grid.5386.8) | |
| 700 | 1 | |a Elhadad, Sara |u Clinical Research Core, Weill Cornell Medicine – Qatar, Doha, Qatar (GRID:grid.5386.8) | |
| 700 | 1 | |a Ahmed, Salma Hayder |u Clinical Research Core, Weill Cornell Medicine – Qatar, Doha, Qatar (GRID:grid.5386.8) | |
| 700 | 1 | |a Omar, Omar |u Clinical Research Core, Weill Cornell Medicine – Qatar, Doha, Qatar (GRID:grid.5386.8) | |
| 700 | 1 | |a Payra, Sherryl |u Clinical Research Core, Weill Cornell Medicine – Qatar, Doha, Qatar (GRID:grid.5386.8) | |
| 700 | 1 | |a Ahmed, Salma |u Clinical Research Core, Weill Cornell Medicine – Qatar, Doha, Qatar (GRID:grid.5386.8) | |
| 700 | 1 | |a El Khatib, Neda |u Qatar Diabetes Association, Qatar Foundation, Doha, Qatar (GRID:grid.418818.c) (ISNI:0000 0001 0516 2170) | |
| 700 | 1 | |a Amona, Rasha Abou |u Qatar Diabetes Association, Qatar Foundation, Doha, Qatar (GRID:grid.418818.c) (ISNI:0000 0001 0516 2170) | |
| 700 | 1 | |a El Nahas, Katie |u Qatar Diabetes Association, Qatar Foundation, Doha, Qatar (GRID:grid.418818.c) (ISNI:0000 0001 0516 2170) | |
| 700 | 1 | |a Bolton, Matthew |u Clinical Research Core, Weill Cornell Medicine – Qatar, Doha, Qatar (GRID:grid.418818.c) | |
| 700 | 1 | |a Chaar, Henem |u Clinical Research Core, Weill Cornell Medicine – Qatar, Doha, Qatar (GRID:grid.418818.c) | |
| 700 | 1 | |a Suleiman, Noor |u Department of Diabetes and Endocrinology, Hamad Medical Corporation, Doha, Qatar (GRID:grid.413548.f) (ISNI:0000 0004 0571 546X) | |
| 700 | 1 | |a Jayyousi, Amin |u Department of Diabetes and Endocrinology, Hamad Medical Corporation, Doha, Qatar (GRID:grid.413548.f) (ISNI:0000 0004 0571 546X) | |
| 700 | 1 | |a Zirie, Mahmoud |u Department of Diabetes and Endocrinology, Hamad Medical Corporation, Doha, Qatar (GRID:grid.413548.f) (ISNI:0000 0004 0571 546X) | |
| 700 | 1 | |a Janahi, Ibrahim |u Department of Diabetes and Endocrinology, Hamad Medical Corporation, Doha, Qatar (GRID:grid.413548.f) (ISNI:0000 0004 0571 546X) | |
| 700 | 1 | |a Elhag, Wahiba |u Qatar Metabolic Institute (QMI), Department of Medicine, Hamad Medical Corporation, Doha, Qatar (GRID:grid.413548.f) (ISNI:0000 0004 0571 546X) | |
| 700 | 1 | |a Alnaama, Abdulla |u Primary Health Care Corporation, Doha, Qatar (GRID:grid.498624.5) (ISNI:0000 0004 4676 5308) | |
| 700 | 1 | |a Zainel, Abduljaleel |u Primary Health Care Corporation, Doha, Qatar (GRID:grid.498624.5) (ISNI:0000 0004 4676 5308) | |
| 700 | 1 | |a Hassan, Dahlia |u Primary Health Care Corporation, Doha, Qatar (GRID:grid.498624.5) (ISNI:0000 0004 4676 5308) | |
| 700 | 1 | |a Cable, Tim |u Aspire Academy, Doha, Qatar (GRID:grid.417586.9) (ISNI:0000 0004 0421 7725) | |
| 700 | 1 | |a Charlson, Mary |u Weill Cornell Medicine – New York, Joan and Sanford I. Weill Department of Medicine, New York, USA (GRID:grid.5386.8) (ISNI:000000041936877X) | |
| 700 | 1 | |a Wells, Martin |u Cornell University, Department of Statistical Science, Ithaca, USA (GRID:grid.5386.8) (ISNI:000000041936877X) | |
| 700 | 1 | |a Al-Hamaq, Abdulla |u Qatar Diabetes Association, Qatar Foundation, Doha, Qatar (GRID:grid.418818.c) (ISNI:0000 0001 0516 2170) | |
| 700 | 1 | |a Al-Abdulla, Samya |u Primary Health Care Corporation, Doha, Qatar (GRID:grid.498624.5) (ISNI:0000 0004 4676 5308) | |
| 700 | 1 | |a Abou-Samra, Abdul Badi |u Department of Medicine, Weill Cornell Medicine – Qatar, Doha, Qatar (GRID:grid.498624.5); Qatar Metabolic Institute (QMI), Department of Medicine, Hamad Medical Corporation, Doha, Qatar (GRID:grid.413548.f) (ISNI:0000 0004 0571 546X); Department of Diabetes and Endocrinology, Hamad Medical Corporation, Doha, Qatar (GRID:grid.413548.f) (ISNI:0000 0004 0571 546X) | |
| 773 | 0 | |t Trials |g vol. 19, no. 1 (Dec 2018), p. 284 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
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