Nicotinamide adenine dinucleotide (NAD+) reduction enabled by an atomically precise Au-Ag alloy nanocluster
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| Publicado en: | Nano Research vol. 16, no. 5 (May 2023), p. 7770 |
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Tsinghua University Press
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| Acceso en línea: | Citation/Abstract Full Text - PDF |
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| 100 | 1 | |a Chen, Ling |u Anhui University, Department of Chemistry and Centre for Atomic Engineering of Advanced Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Physical Science and Information Technology and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Hefei, China (GRID:grid.252245.6) (ISNI:0000 0001 0085 4987); Hefei Comprehensive National Science Center, Institute of Energy, Hefei, China (GRID:grid.513034.0) | |
| 245 | 1 | |a Nicotinamide adenine dinucleotide (NAD<sup>+</sup>) reduction enabled by an atomically precise Au-Ag alloy nanocluster | |
| 260 | |b Tsinghua University Press |c May 2023 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a The redox property of the ultrasmall coinage nanoclusters (with several to tens of Au/Ag atoms) has elucidated the electron-transfer capacity of nanoclusters, and has been successfully utilized in a variety of redox conversions (such as from CO2 to CO). Nevertheless, their biological applications are mainly restricted by the scarcity of atomically precise, water-soluble metal nanoclusters, and the limited application (mainly on the decomposition of H2O2 in these days). Herein, mercaptosuccinic acid (MSA) protected ultrasmall alloy AuAg nanoclusters were prepared, and the main product was determined [Au3Ag5(MSA)3]− by electrospray ionization mass spectrometry (ESI-MS). The clusters can not only mediate the decomposition of H2O2 to generate hydroxyl radicals, but is also able to mediate the reduction of nicotinamide adenine dinucleotide (NAD) to its reduced form of NADH. This is the first time that the atomically precise metal nanoclusters were used to mediate the coenzyme reduction. The preliminary mechanistic insights imply the reaction to be driven by the hydrogen bonding between the carboxylic groups (on the surface of MSA) and the amino N—H bonds (on NAD). In this context, the presence of the carboxylic groups, the sub-nanometer size regime (∼ 1 nm), and the synergistic effect of the Au-Ag clusters are pre-requisite to the NAD reduction. | |
| 653 | |a Mass spectrometry | ||
| 653 | |a Adenine | ||
| 653 | |a Gold base alloys | ||
| 653 | |a Hydrogen peroxide | ||
| 653 | |a Ions | ||
| 653 | |a Decomposition | ||
| 653 | |a Clusters | ||
| 653 | |a Carbon dioxide | ||
| 653 | |a Hydrogen bonding | ||
| 653 | |a Hydroxyl radicals | ||
| 653 | |a Gold | ||
| 653 | |a NAD | ||
| 653 | |a Nicotinamide adenine dinucleotide | ||
| 653 | |a Ionization | ||
| 653 | |a Synergistic effect | ||
| 653 | |a Water scarcity | ||
| 653 | |a Mass spectroscopy | ||
| 653 | |a Nanoclusters | ||
| 653 | |a Free radicals | ||
| 653 | |a Silver | ||
| 653 | |a Nicotinamide | ||
| 653 | |a Environmental | ||
| 700 | 1 | |a Du, Yonglei |u Anhui University, Department of Chemistry and Centre for Atomic Engineering of Advanced Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Physical Science and Information Technology and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Hefei, China (GRID:grid.252245.6) (ISNI:0000 0001 0085 4987) | |
| 700 | 1 | |a Lv, Ying |u Anhui University, Department of Chemistry and Centre for Atomic Engineering of Advanced Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Physical Science and Information Technology and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Hefei, China (GRID:grid.252245.6) (ISNI:0000 0001 0085 4987) | |
| 700 | 1 | |a Fan, Daoqing |u Anhui University, Department of Chemistry and Centre for Atomic Engineering of Advanced Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Physical Science and Information Technology and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Hefei, China (GRID:grid.252245.6) (ISNI:0000 0001 0085 4987) | |
| 700 | 1 | |a Wu, Junfei |u Anhui University, Department of Chemistry and Centre for Atomic Engineering of Advanced Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Physical Science and Information Technology and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Hefei, China (GRID:grid.252245.6) (ISNI:0000 0001 0085 4987) | |
| 700 | 1 | |a Wu, Lingbao |u Anhui University, Department of Chemistry and Centre for Atomic Engineering of Advanced Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Physical Science and Information Technology and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Hefei, China (GRID:grid.252245.6) (ISNI:0000 0001 0085 4987) | |
| 700 | 1 | |a Cui, Mengting |u Anhui University, Department of Chemistry and Centre for Atomic Engineering of Advanced Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Physical Science and Information Technology and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Hefei, China (GRID:grid.252245.6) (ISNI:0000 0001 0085 4987) | |
| 700 | 1 | |a Yu, Haizhu |u Anhui University, Department of Chemistry and Centre for Atomic Engineering of Advanced Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Physical Science and Information Technology and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Hefei, China (GRID:grid.252245.6) (ISNI:0000 0001 0085 4987); Hefei Comprehensive National Science Center, Institute of Energy, Hefei, China (GRID:grid.513034.0) | |
| 700 | 1 | |a Zhu, Manzhou |u Anhui University, Department of Chemistry and Centre for Atomic Engineering of Advanced Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Physical Science and Information Technology and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Hefei, China (GRID:grid.252245.6) (ISNI:0000 0001 0085 4987) | |
| 773 | 0 | |t Nano Research |g vol. 16, no. 5 (May 2023), p. 7770 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/2817259477/abstract/embedded/75I98GEZK8WCJMPQ?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/2817259477/fulltextPDF/embedded/75I98GEZK8WCJMPQ?source=fedsrch |