Successful treatment with enfortumab–vedotin of metastatic signet ring cell cancer expressing nectin-4 and originating from the bladder
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | IJU Case Reports vol. 7, no. 2 (Mar 2024), p. 110 |
|---|---|
| Prif Awdur: | |
| Awduron Eraill: | , , , , , , , , |
| Cyhoeddwyd: |
John Wiley & Sons, Inc.
|
| Pynciau: | |
| Mynediad Ar-lein: | Citation/Abstract Full Text + Graphics Full Text - PDF |
| Tagiau: |
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
|
MARC
| LEADER | 00000nab a2200000uu 4500 | ||
|---|---|---|---|
| 001 | 2933872849 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2577-171X | ||
| 024 | 7 | |a 10.1002/iju5.12678 |2 doi | |
| 035 | |a 2933872849 | ||
| 045 | 2 | |b d20240301 |b d20240331 | |
| 100 | 1 | |a Aoki, Maria |u Department of Nephro-urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan | |
| 245 | 1 | |a Successful treatment with enfortumab–vedotin of metastatic signet ring cell cancer expressing nectin-4 and originating from the bladder | |
| 260 | |b John Wiley & Sons, Inc. |c Mar 2024 | ||
| 513 | |a Journal Article Case Study | ||
| 520 | 3 | |a IntroductionAs an aggressive adenocarcinoma phenotype, primary signet ring cell carcinoma of the urinary bladder is an extremely rare variant. The prognosis of metastatic signet ring cell carcinoma of the urinary bladder is extremely poor and the clinical course for its specific pathogenesis remains unelucidated.Case presentationA 64-year-old Japanese male patient was diagnosed with invasive urothelial carcinoma with glandular differentiation of a signet ring cell–type with pT4aN0M0, and he was eventually diagnosed with metastatic signet ring cell carcinoma of the urinary bladder. He was initially responsive to systemic combination induction chemotherapy of S-1 and cisplatin followed by avelumab switch maintenance therapy; however, signet ring cell carcinoma of the urinary bladder relapse occurred in the pathological findings of a biopsy from the right thigh. Immunohistochemical analysis of this specimen identified strong positive staining for nectin-4 and, following enfortumab–vedotin treatment, the patient showed a good response.ConclusionWe thus describe a rare case of metastatic signet ring cell carcinoma of the urinary bladder with nectin-4 expression diagnosed by a biopsy of a metastatic site. | |
| 651 | 4 | |a Japan | |
| 653 | |a Patients | ||
| 653 | |a Medical prognosis | ||
| 653 | |a Metastasis | ||
| 653 | |a Antibodies | ||
| 653 | |a Musculoskeletal system | ||
| 653 | |a Cancer therapies | ||
| 653 | |a Magnetic resonance imaging | ||
| 653 | |a Biopsy | ||
| 653 | |a Edema | ||
| 653 | |a Body fat | ||
| 653 | |a Conflicts of interest | ||
| 653 | |a Bladder cancer | ||
| 653 | |a Informed consent | ||
| 653 | |a Urological surgery | ||
| 653 | |a Chemotherapy | ||
| 653 | |a Case reports | ||
| 653 | |a Monoclonal antibodies | ||
| 653 | |a Targeted cancer therapy | ||
| 653 | |a Immunotherapy | ||
| 700 | 1 | |a Naiki, Taku |u Department of Nephro-urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan | |
| 700 | 1 | |a Naiki-Ito, Aya |u Department of Experimental Pathology and Tumor Biology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan | |
| 700 | 1 | |a Morikawa, Toshiharu |u Department of Nephro-urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan | |
| 700 | 1 | |a Matsuyama, Nayuka |u Department of Nephro-urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan | |
| 700 | 1 | |a Torii, Koei |u Department of Nephro-urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan | |
| 700 | 1 | |a Kato, Taiki |u Department of Urology, Nagoya City University East Medical Center, Nagoya, Japan | |
| 700 | 1 | |a Maruyama, Tetsuji |u Department of Urology, Nagoya City University East Medical Center, Nagoya, Japan | |
| 700 | 1 | |a Inaguma, Shingo |u Department of Experimental Pathology and Tumor Biology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan | |
| 700 | 1 | |a Yasui, Takahiro |u Department of Nephro-urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan | |
| 773 | 0 | |t IJU Case Reports |g vol. 7, no. 2 (Mar 2024), p. 110 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/2933872849/abstract/embedded/75I98GEZK8WCJMPQ?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text + Graphics |u https://www.proquest.com/docview/2933872849/fulltextwithgraphics/embedded/75I98GEZK8WCJMPQ?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/2933872849/fulltextPDF/embedded/75I98GEZK8WCJMPQ?source=fedsrch |