Feasibility of a “No-Biopsy” Approach for the Diagnosis of Celiac Disease in Symptomatic Adults
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| Publicado no: | Cureus vol. 16, no. 2 (2024) |
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| Autor principal: | |
| Outros Autores: | , , , , , , , |
| Publicado em: |
Springer Nature B.V.
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| Acesso em linha: | Citation/Abstract Full Text + Graphics Full Text - PDF |
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| 024 | 7 | |a 10.7759/cureus.54578 |2 doi | |
| 035 | |a 3020791968 | ||
| 045 | 2 | |b d20240101 |b d20241231 | |
| 100 | 1 | |a Punia Parul | |
| 245 | 1 | |a Feasibility of a “No-Biopsy” Approach for the Diagnosis of Celiac Disease in Symptomatic Adults | |
| 260 | |b Springer Nature B.V. |c 2024 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Celiac disease (CD) is an immune-mediated enteropathy, caused by hypersensitivity to gluten in genetically predisposed individuals. The worldwide prevalence of CD has been estimated to be approximately 1%. Most guidelines for diagnosis of CD rely on a sequential approach, with serological testing of antibodies against tissue transglutaminase (tTG) as a first-line test, followed by a duodenal biopsy. However, GI biopsy is an invasive procedure with various complications. Hence, this study was planned to ascertain whether it could be possible to have a non-biopsy approach, using only serological markers to establish the diagnosis of CD in adults.Material and methods: It was a retrospective analysis of medical records of all biopsy-diagnosed CD patients with available anti-tTGA antibodies reports from 2019 to 2023. The patients were divided into three groups based on Marsh grading and anti-tTGA antibody levels were compared using various statistical tests.Results: A total of 94 biopsy-diagnosed symptomatic CD patients with anti-tTGA antibody reports available formed the study group. Of these, 54 had biopsy findings consistent with Marsh 3 lesion, three had Marsh 2 lesion, and 37 had Marsh 1 lesion. A significant correlation existed between Marsh grading 3 lesion and anti-tTGA antibody levels above the upper limit of normal (ULN) x 10.Conclusion: Serum levels of anti-tTGA antibodies greater than 10 x ULN can be used to identify symptomatic patients with Marsh grade 3 CD lesions. | |
| 651 | 4 | |a India | |
| 653 | |a Histology | ||
| 653 | |a Antigens | ||
| 653 | |a Antibodies | ||
| 653 | |a Pediatrics | ||
| 653 | |a Celiac disease | ||
| 653 | |a Serology | ||
| 653 | |a Biopsy | ||
| 653 | |a Medical research | ||
| 653 | |a Medical diagnosis | ||
| 653 | |a Teenagers | ||
| 700 | 1 | |a Bala Kiran | |
| 700 | 1 | |a Verma Mansi | |
| 700 | 1 | |a Nandi Ankita | |
| 700 | 1 | |a Mahlotra Parveen | |
| 700 | 1 | |a Singh, Sunita | |
| 700 | 1 | |a Garg Seema | |
| 700 | 1 | |a Parmar Aparna | |
| 700 | 1 | |a Kumar, Devender | |
| 773 | 0 | |t Cureus |g vol. 16, no. 2 (2024) | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3020791968/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text + Graphics |u https://www.proquest.com/docview/3020791968/fulltextwithgraphics/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3020791968/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |