Evaluation of a scoring system to predict treatment success with single-dose methotrexate in ectopic pregnancy
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| Publicado en: | Archives of Gynecology and Obstetrics vol. 309, no. 5 (May 2024), p. 2047 |
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| Otros Autores: | , , , |
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Springer Nature B.V.
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| Acceso en línea: | Citation/Abstract Full Text - PDF |
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| 001 | 3038448288 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 0932-0067 | ||
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| 022 | |a 0003-9128 | ||
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| 024 | 7 | |a 10.1007/s00404-024-07458-6 |2 doi | |
| 035 | |a 3038448288 | ||
| 045 | 2 | |b d20240501 |b d20240531 | |
| 100 | 1 | |a Yeniocak, Ali Selcuk |u Basaksehir Cam and Sakura City Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey (ISNI:0000 0005 0683 0715) | |
| 245 | 1 | |a Evaluation of a scoring system to predict treatment success with single-dose methotrexate in ectopic pregnancy | |
| 260 | |b Springer Nature B.V. |c May 2024 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a PurposeThis study sought to assess the efficacy of a newly developed scoring system in predicting treatment outcomes for ectopic pregnancy among patients undergoing single-dose methotrexate therapy. The primary research question centered on the reliability and predictive accuracy of objective parameters in determining methotrexate therapy success.MethodsConducted as a retrospective single-center cohort study, data from 172 ectopic pregnancy patients treated with methotrexate between January 2021 and January 2023 were analyzed. Parameters including adnexal mass size, peritoneal fluid presence, yolk sac identification, endometrial thickness, ectopic pregnancy location, and initial B-hCG levels were meticulously evaluated for their association with treatment outcomes.ResultsFollowing the exclusion of 21 emergency surgery cases, the final analysis comprised 151 patients. Notable associations were observed between specific parameters (fetal cardiac activity, adnexal mass size > 3.5 cm, peritoneal fluid presence, yolk sac identification, endometrial thickness > 10 mm, and initial B-hCG levels) and treatment outcomes (p < 0.001). Additionally, the novel scoring system demonstrated promising predictive performance. At a cutoff of 2.50, it achieved a sensitivity of 91.7% and a specificity of 59.7%. Increasing the cutoff to 3.50 resulted in a sensitivity of 94.0%, with a specificity of 46.3%.ConclusionObjective parameters, particularly those integrated into the developed scoring system, exhibited substantial associations with methotrexate therapy outcomes in ectopic pregnancy. These findings underscore the potential of an objective scoring model to significantly influence clinical decision-making in therapy, offering avenues for enhanced prognostication and patient care in treatment outcomes. | |
| 653 | |a Pregnancy complications | ||
| 653 | |a Clinical outcomes | ||
| 653 | |a Drug dosages | ||
| 700 | 1 | |a Tercan, Can |u Basaksehir Cam and Sakura City Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey (ISNI:0000 0005 0683 0715) | |
| 700 | 1 | |a Dagdeviren, Emrah |u Basaksehir Cam and Sakura City Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey (ISNI:0000 0005 0683 0715) | |
| 700 | 1 | |a Arabacı, Onur |u Basaksehir Cam and Sakura City Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey (ISNI:0000 0005 0683 0715) | |
| 700 | 1 | |a Genc, Emine Elif |u Basaksehir Cam and Sakura City Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey (ISNI:0000 0005 0683 0715) | |
| 773 | 0 | |t Archives of Gynecology and Obstetrics |g vol. 309, no. 5 (May 2024), p. 2047 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3038448288/abstract/embedded/75I98GEZK8WCJMPQ?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3038448288/fulltextPDF/embedded/75I98GEZK8WCJMPQ?source=fedsrch |