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022 |a 2306-5354 
024 7 |a 10.3390/bioengineering11080821  |2 doi 
035 |a 3097834172 
045 2 |b d20240101  |b d20241231 
100 1 |a Tang, Feifang  |u Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan 430074, China; <email>tangfeifang@hust.edu.cn</email> (F.T.); <email>feiyangyan@hust.edu.cn</email> (F.Y.); <email>zoezhongys@gmail.com</email> (Y.Z.); <email>jinqian_li@brown.edu</email> (J.L.); <email>huigong@mail.hust.edu.cn</email> (H.G.) 
245 1 |a Optogenetic Brain–Computer Interfaces 
260 |b MDPI AG  |c 2024 
513 |a Journal Article 
520 3 |a The brain–computer interface (BCI) is one of the most powerful tools in neuroscience and generally includes a recording system, a processor system, and a stimulation system. Optogenetics has the advantages of bidirectional regulation, high spatiotemporal resolution, and cell-specific regulation, which expands the application scenarios of BCIs. In recent years, optogenetic BCIs have become widely used in the lab with the development of materials and software. The systems were designed to be more integrated, lightweight, biocompatible, and power efficient, as were the wireless transmission and chip-level embedded BCIs. The software is also constantly improving, with better real-time performance and accuracy and lower power consumption. On the other hand, as a cutting-edge technology spanning multidisciplinary fields including molecular biology, neuroscience, material engineering, and information processing, optogenetic BCIs have great application potential in neural decoding, enhancing brain function, and treating neural diseases. Here, we review the development and application of optogenetic BCIs. In the future, combined with other functional imaging techniques such as near-infrared spectroscopy (fNIRS) and functional magnetic resonance imaging (fMRI), optogenetic BCIs can modulate the function of specific circuits, facilitate neurological rehabilitation, assist perception, establish a brain-to-brain interface, and be applied in wider application scenarios. 
653 |a Brain 
653 |a Imaging techniques 
653 |a Software 
653 |a Magnetic resonance imaging 
653 |a Data processing 
653 |a Functional magnetic resonance imaging 
653 |a Electrodes 
653 |a Animals 
653 |a Microprocessors 
653 |a Brain research 
653 |a Signal processing 
653 |a Medical imaging 
653 |a Biochips 
653 |a Implants 
653 |a Computer applications 
653 |a Power consumption 
653 |a Infrared imaging 
653 |a Molecular biology 
653 |a Genetics 
653 |a Human subjects 
653 |a Infrared spectra 
653 |a Optics 
653 |a Neurons 
653 |a Human-computer interface 
653 |a Signal to noise ratio 
653 |a Functional morphology 
653 |a Near infrared radiation 
653 |a Infrared spectroscopy 
653 |a Brain mapping 
653 |a Genetic engineering 
653 |a Power management 
653 |a Biocompatibility 
653 |a Information processing 
653 |a Real time 
653 |a Neuroimaging 
653 |a Ultrasonic imaging 
653 |a Neural coding 
700 1 |a Feiyang Yan  |u Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan 430074, China; <email>tangfeifang@hust.edu.cn</email> (F.T.); <email>feiyangyan@hust.edu.cn</email> (F.Y.); <email>zoezhongys@gmail.com</email> (Y.Z.); <email>jinqian_li@brown.edu</email> (J.L.); <email>huigong@mail.hust.edu.cn</email> (H.G.) 
700 1 |a Zhong, Yushan  |u Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan 430074, China; <email>tangfeifang@hust.edu.cn</email> (F.T.); <email>feiyangyan@hust.edu.cn</email> (F.Y.); <email>zoezhongys@gmail.com</email> (Y.Z.); <email>jinqian_li@brown.edu</email> (J.L.); <email>huigong@mail.hust.edu.cn</email> (H.G.) 
700 1 |a Li, Jinqian  |u Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan 430074, China; <email>tangfeifang@hust.edu.cn</email> (F.T.); <email>feiyangyan@hust.edu.cn</email> (F.Y.); <email>zoezhongys@gmail.com</email> (Y.Z.); <email>jinqian_li@brown.edu</email> (J.L.); <email>huigong@mail.hust.edu.cn</email> (H.G.) 
700 1 |a Gong, Hui  |u Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan 430074, China; <email>tangfeifang@hust.edu.cn</email> (F.T.); <email>feiyangyan@hust.edu.cn</email> (F.Y.); <email>zoezhongys@gmail.com</email> (Y.Z.); <email>jinqian_li@brown.edu</email> (J.L.); <email>huigong@mail.hust.edu.cn</email> (H.G.) 
700 1 |a Li, Xiangning  |u Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou 570228, China 
773 0 |t Bioengineering  |g vol. 11, no. 8 (2024), p. 821 
786 0 |d ProQuest  |t Engineering Database 
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