Vitamin B12 status and skeletal muscle function among elderly: A literature review and pilot study on the effect of oral vitamin B12 supplementation in improving muscle function
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| Udgivet i: | Aging Medicine vol. 7, no. 4 (Aug 1, 2024), p. 480 |
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John Wiley & Sons, Inc.
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MARC
| LEADER | 00000nab a2200000uu 4500 | ||
|---|---|---|---|
| 001 | 3099978418 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2475-0360 | ||
| 024 | 7 | |a 10.1002/agm2.12346 |2 doi | |
| 035 | |a 3099978418 | ||
| 045 | 0 | |b d20240801 | |
| 100 | 1 | |a Sharma, Sowmya |u Department of Physiology, St. John's Medical College, Bangalore, India | |
| 245 | 1 | |a Vitamin B12 status and skeletal muscle function among elderly: A literature review and pilot study on the effect of oral vitamin B12 supplementation in improving muscle function | |
| 260 | |b John Wiley & Sons, Inc. |c Aug 1, 2024 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Objectives The objective of this study is to understand the role of vitamin B12 supplementation in improving skeletal muscle function among the elderly. Methods A literature review in the Medline database was conducted to understand the association between vitamin B12 and muscle function in Section A. In Section B, 28 healthy elderly participants aged ≥60 years were recruited in a cross‐sectional design for estimation of plasma vitamin B12 status and assessment of upper limb muscle strength Maximal voluntary contraction (MVC) and muscle quality (expressed as MVC/total muscle mass). Participants were grouped based on vitamin B12 status into vitamin B12‐depleted (<148 pmol/L) and replete (≥148 pmol/L) groups. In a quasi‐experimental study design, the vitamin B12‐depleted group (n = 14) received daily oral vitamin B12 supplementation of 100 μg for 3 months. All the study measures were repeated post‐supplementation. Results Vitamin B12 deficiency was identified to contribute adversely to muscle strength, quality, and physical performance among older people in the extensive literature review. The pilot intervention study showed significant improvement in MVC and muscle quality (p < 0.050) post‐vitamin B12 supplementation, comparable to the vitamin B12‐replete group. Conclusions Vitamin B12 may have a crucial role in the maintenance of muscle function. 3‐month oral vitamin B12 supplementation among subclinical vitamin B12 deficient elderly improved muscle strength and quality and reached levels similar to the vitamin B12 replete group. | |
| 653 | |a Gait | ||
| 653 | |a Frailty | ||
| 653 | |a Muscle strength | ||
| 653 | |a Age | ||
| 653 | |a Pilot projects | ||
| 653 | |a Sarcopenia | ||
| 653 | |a Musculoskeletal system | ||
| 653 | |a Cross-sectional studies | ||
| 653 | |a Aging | ||
| 653 | |a Nutrition research | ||
| 653 | |a Older people | ||
| 653 | |a Literature reviews | ||
| 653 | |a Muscle function | ||
| 653 | |a Metabolites | ||
| 653 | |a Mobility | ||
| 653 | |a Longitudinal studies | ||
| 653 | |a Vegetarianism | ||
| 700 | 1 | |a Bhadra, Rohini |u Division of Clinical Physiology, Department of Physiology, St. John's Medical College &amp; St. John's Research Institute, Bangalore, India | |
| 700 | 1 | |a Selvam, Sumithra |u Division of Epidemiology, Biostatistics and Population Health, St John's Research Institute, Bangalore, India | |
| 700 | 1 | |a Sambashivaiah, Sucharita |u Department of Physiology, St. John's Medical College, Bangalore, India | |
| 773 | 0 | |t Aging Medicine |g vol. 7, no. 4 (Aug 1, 2024), p. 480 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3099978418/abstract/embedded/H09TXR3UUZB2ISDL?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text |u https://www.proquest.com/docview/3099978418/fulltext/embedded/H09TXR3UUZB2ISDL?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3099978418/fulltextPDF/embedded/H09TXR3UUZB2ISDL?source=fedsrch |