Evolution of SARS-CoV-2 in the murine central nervous system drives viral diversification
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| Publicado en: | Nature Microbiology vol. 9, no. 9 (Sep 2024), p. 2383 |
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| Autor principal: | |
| Otros Autores: | , , , , , , , , , , |
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Nature Publishing Group
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| Acceso en línea: | Citation/Abstract Full Text - PDF |
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| 001 | 3100359755 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2058-5276 | ||
| 024 | 7 | |a 10.1038/s41564-024-01786-8 |2 doi | |
| 035 | |a 3100359755 | ||
| 045 | 2 | |b d20240901 |b d20240930 | |
| 100 | 1 | |a Class, Jacob |u University of Illinois Chicago, Department of Microbiology and Immunology, College of Medicine, Chicago, USA (GRID:grid.185648.6) (ISNI:0000 0001 2175 0319) | |
| 245 | 1 | |a Evolution of SARS-CoV-2 in the murine central nervous system drives viral diversification | |
| 260 | |b Nature Publishing Group |c Sep 2024 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Severe coronavirus disease 2019 and post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are associated with neurological complications that may be linked to direct infection of the central nervous system (CNS), but the selective pressures ruling neuroinvasion are poorly defined. Here we assessed SARS-CoV-2 evolution in the lung versus CNS of infected mice. Higher levels of viral divergence were observed in the CNS than the lung after intranasal challenge with a high frequency of mutations in the spike furin cleavage site (FCS). Deletion of the FCS significantly attenuated virulence after intranasal challenge, with lower viral titres and decreased morbidity compared with the wild-type virus. Intracranial inoculation of the FCS-deleted virus, however, was sufficient to restore virulence. After intracranial inoculation, both viruses established infection in the lung, but dissemination from the CNS to the lung required the intact FCS. Cumulatively, these data suggest a critical role for the FCS in determining SARS-CoV-2 tropism and compartmentalization.SARS-CoV-2 replication in the murine lung requires the spike furin cleavage site, which is then lost during divergence in the brain. | |
| 653 | |a Infections | ||
| 653 | |a Coronaviruses | ||
| 653 | |a Neurological complications | ||
| 653 | |a Morbidity | ||
| 653 | |a Furin | ||
| 653 | |a Severe acute respiratory syndrome coronavirus 2 | ||
| 653 | |a Gene deletion | ||
| 653 | |a Inoculation | ||
| 653 | |a Virulence | ||
| 653 | |a Lungs | ||
| 653 | |a Nervous system | ||
| 653 | |a COVID-19 | ||
| 653 | |a Central nervous system | ||
| 653 | |a Divergence | ||
| 653 | |a Tropism | ||
| 653 | |a Invasiveness | ||
| 700 | 1 | |a Simons, Lacy M. |u Northwestern University, Department of Medicine, Division of Infectious Diseases, Feinberg School of Medicine, Chicago, USA (GRID:grid.16753.36) (ISNI:0000 0001 2299 3507); Northwestern University, Center for Pathogen Genomics and Microbial Evolution, Havey Institute for Global Health, Feinberg School of Medicine, Chicago, USA (GRID:grid.16753.36) (ISNI:0000 0001 2299 3507) | |
| 700 | 1 | |a Lorenzo-Redondo, Ramon |u Northwestern University, Department of Medicine, Division of Infectious Diseases, Feinberg School of Medicine, Chicago, USA (GRID:grid.16753.36) (ISNI:0000 0001 2299 3507); Northwestern University, Center for Pathogen Genomics and Microbial Evolution, Havey Institute for Global Health, Feinberg School of Medicine, Chicago, USA (GRID:grid.16753.36) (ISNI:0000 0001 2299 3507) | |
| 700 | 1 | |a Achi, Jazmin Galván |u University of Illinois Chicago, Department of Microbiology and Immunology, College of Medicine, Chicago, USA (GRID:grid.185648.6) (ISNI:0000 0001 2175 0319) | |
| 700 | 1 | |a Cooper, Laura |u University of Illinois Chicago, Department of Microbiology and Immunology, College of Medicine, Chicago, USA (GRID:grid.185648.6) (ISNI:0000 0001 2175 0319) | |
| 700 | 1 | |a Dangi, Tanushree |u Northwestern University, Department of Microbiology-Immunology, Feinberg School of Medicine, Chicago, USA (GRID:grid.16753.36) (ISNI:0000 0001 2299 3507) | |
| 700 | 1 | |a Penaloza-MacMaster, Pablo |u Northwestern University, Department of Microbiology-Immunology, Feinberg School of Medicine, Chicago, USA (GRID:grid.16753.36) (ISNI:0000 0001 2299 3507) | |
| 700 | 1 | |a Ozer, Egon A. |u Northwestern University, Department of Medicine, Division of Infectious Diseases, Feinberg School of Medicine, Chicago, USA (GRID:grid.16753.36) (ISNI:0000 0001 2299 3507); Northwestern University, Center for Pathogen Genomics and Microbial Evolution, Havey Institute for Global Health, Feinberg School of Medicine, Chicago, USA (GRID:grid.16753.36) (ISNI:0000 0001 2299 3507) | |
| 700 | 1 | |a Lutz, Sarah E. |u University of Illinois Chicago, Department of Anatomy and Cell Biology, College of Medicine, Chicago, USA (GRID:grid.185648.6) (ISNI:0000 0001 2175 0319) | |
| 700 | 1 | |a Rong, Lijun |u University of Illinois Chicago, Department of Microbiology and Immunology, College of Medicine, Chicago, USA (GRID:grid.185648.6) (ISNI:0000 0001 2175 0319) | |
| 700 | 1 | |a Hultquist, Judd F. |u Northwestern University, Department of Medicine, Division of Infectious Diseases, Feinberg School of Medicine, Chicago, USA (GRID:grid.16753.36) (ISNI:0000 0001 2299 3507); Northwestern University, Center for Pathogen Genomics and Microbial Evolution, Havey Institute for Global Health, Feinberg School of Medicine, Chicago, USA (GRID:grid.16753.36) (ISNI:0000 0001 2299 3507) | |
| 700 | 1 | |a Richner, Justin M. |u University of Illinois Chicago, Department of Microbiology and Immunology, College of Medicine, Chicago, USA (GRID:grid.185648.6) (ISNI:0000 0001 2175 0319) | |
| 773 | 0 | |t Nature Microbiology |g vol. 9, no. 9 (Sep 2024), p. 2383 | |
| 786 | 0 | |d ProQuest |t Biological Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3100359755/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3100359755/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |