Patient-Reported Outcomes 10 Years After Breast-Conserving Surgery for Early-Stage Breast Cancer
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| Publicat a: | Annals of Surgical Oncology vol. 31, no. 10 (Oct 2024), p. 6831 |
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| Autor principal: | |
| Altres autors: | , , , , , , |
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Springer Nature B.V.
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| Accés en línia: | Citation/Abstract Full Text - PDF |
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| 100 | 1 | |a Dominici, Laura S. |u Brigham and Women’s Hospital, Division of Breast Surgery, Department of Surgery, Boston, USA (GRID:grid.62560.37) (ISNI:0000 0004 0378 8294); Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, USA (GRID:grid.417747.6) (ISNI:0000 0004 0460 3896); Harvard Medical School, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X) | |
| 245 | 1 | |a Patient-Reported Outcomes 10 Years After Breast-Conserving Surgery for Early-Stage Breast Cancer | |
| 260 | |b Springer Nature B.V. |c Oct 2024 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a BackgroundPatient-reported outcomes (PROs) are a critical component of value-based care. Limited data exist describing long-term PROs in patients undergoing breast-conserving surgery (BCS).Patients and MethodsPatients undergoing surgery for stage 0–III breast cancer at our institution from 2002 to 2012 who agreed to be contacted were invited to participate in a cross-sectional PRO study. Health-related quality of life outcomes using BREAST-Q, EORTC QLQ-C30, and EORTC QLQ-BR45 were collected. Patients reporting chemotherapy within 6 months of receiving the survey were excluded. For this work, we focused on patients who underwent BCS. Multivariable linear regression was performed to identify factors associated with PRO scores, adjusting for age, time since surgery, anatomic stage, molecular subtype, receipt of systemic and/or radiation therapy (RT), locoregional recurrence, or contralateral breast cancer.ResultsAmong 562 interested and eligible patients, 437 (78%) responded; median time from surgery to survey completion was 10.4 years (interquartile range: 8.0–13.5). Median age at surgery was 53 years (standard deviation 9.8 years), ≥ 90% were white, had upfront surgery for early-stage disease, and completed adjuvant RT. Physical and psychological well-being scores were generally high, with more variation seen for sexual well-being and satisfaction with breasts.ConclusionThis study provides long-term PRO data for patients treated with BCS, demonstrating the ongoing association of breast cancer surgery with quality of life in the survivorship period and highlighting the importance of examining PROs beyond the perioperative period. These data also provide important reference values for the interpretation of PROs among women treated with BCS as we move towards value-based care. | |
| 653 | |a Patients | ||
| 653 | |a Quality of life | ||
| 653 | |a Value-based care | ||
| 653 | |a Cancer therapies | ||
| 653 | |a Breast surgery | ||
| 653 | |a Surgery | ||
| 653 | |a Radiation therapy | ||
| 653 | |a Breast cancer | ||
| 653 | |a Surveys | ||
| 653 | |a Chemotherapy | ||
| 653 | |a Survival | ||
| 653 | |a Lumpectomy | ||
| 653 | |a Clinical outcomes | ||
| 653 | |a Well being | ||
| 700 | 1 | |a Laws, Alison |u Brigham and Women’s Hospital, Division of Breast Surgery, Department of Surgery, Boston, USA (GRID:grid.62560.37) (ISNI:0000 0004 0378 8294); Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, USA (GRID:grid.417747.6) (ISNI:0000 0004 0460 3896); Harvard Medical School, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X); University of Calgary, Division of General Surgery, Department of Surgery, Calgary, Canada (GRID:grid.22072.35) (ISNI:0000 0004 1936 7697) | |
| 700 | 1 | |a Lagendijk, Mirelle |u Brigham and Women’s Hospital, Division of Breast Surgery, Department of Surgery, Boston, USA (GRID:grid.62560.37) (ISNI:0000 0004 0378 8294); Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, USA (GRID:grid.417747.6) (ISNI:0000 0004 0460 3896); Erasmus Medical Center, Rotterdam, The Netherlands (GRID:grid.5645.2) (ISNI:000000040459992X) | |
| 700 | 1 | |a Grossmith, Samantha |u Brigham and Women’s Hospital, Division of Breast Surgery, Department of Surgery, Boston, USA (GRID:grid.62560.37) (ISNI:0000 0004 0378 8294); Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, USA (GRID:grid.417747.6) (ISNI:0000 0004 0460 3896) | |
| 700 | 1 | |a Hughes, Melissa |u Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, USA (GRID:grid.417747.6) (ISNI:0000 0004 0460 3896) | |
| 700 | 1 | |a Lin, Nancy |u Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, USA (GRID:grid.417747.6) (ISNI:0000 0004 0460 3896); Harvard Medical School, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X); Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA (GRID:grid.65499.37) (ISNI:0000 0001 2106 9910) | |
| 700 | 1 | |a Mittendorf, Elizabeth A. |u Brigham and Women’s Hospital, Division of Breast Surgery, Department of Surgery, Boston, USA (GRID:grid.62560.37) (ISNI:0000 0004 0378 8294); Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, USA (GRID:grid.417747.6) (ISNI:0000 0004 0460 3896); Harvard Medical School, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X) | |
| 700 | 1 | |a King, Tari A. |u Brigham and Women’s Hospital, Division of Breast Surgery, Department of Surgery, Boston, USA (GRID:grid.62560.37) (ISNI:0000 0004 0378 8294); Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, USA (GRID:grid.417747.6) (ISNI:0000 0004 0460 3896); Harvard Medical School, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X) | |
| 773 | 0 | |t Annals of Surgical Oncology |g vol. 31, no. 10 (Oct 2024), p. 6831 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3110546579/abstract/embedded/J7RWLIQ9I3C9JK51?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3110546579/fulltextPDF/embedded/J7RWLIQ9I3C9JK51?source=fedsrch |