Diverse phage defence systems define West African South American pandemic Vibrio cholerae
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| Foilsithe in: | bioRxiv (Jan 28, 2025) |
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| Príomhchruthaitheoir: | |
| Rannpháirtithe: | , , , , , |
| Foilsithe / Cruthaithe: |
Cold Spring Harbor Laboratory Press
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| Ábhair: | |
| Rochtain ar líne: | Citation/Abstract Full Text - PDF Full text outside of ProQuest |
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Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
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MARC
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| 001 | 3132462547 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2692-8205 | ||
| 024 | 7 | |a 10.1101/2024.11.23.624991 |2 doi | |
| 035 | |a 3132462547 | ||
| 045 | 0 | |b d20250128 | |
| 100 | 1 | |a Adams, David W | |
| 245 | 1 | |a Diverse phage defence systems define West African South American pandemic Vibrio cholerae | |
| 260 | |b Cold Spring Harbor Laboratory Press |c Jan 28, 2025 | ||
| 513 | |a Working Paper | ||
| 520 | 3 | |a Our understanding of the factors underlying the evolutionary success of different lineages of pandemic Vibrio cholerae remains incomplete. Interestingly, two unique genetic signatures define the West African South American (WASA) lineage of V. cholerae responsible for the 1991-2001 Latin American cholera epidemic. Here we show these signatures encode diverse anti-phage defence systems. Firstly, the WASA-1 prophage encodes a 2-gene abortive-infection system WonAB that renders the lineage resistant to the major predatory vibriophage ICP1, which alongside other phages, is thought to restrict cholera epidemics and has potential for use in prophylaxis. Secondly, a unique set of genes on the Vibrio seventh pandemic island II encodes an unusual modification-dependent restriction system targeting phages with modified genomes, and a new member of the Shedu defence family that defends against vibriophage X29. Taken together, we propose that these anti-phage defence systems have likely contributed to the success of a major epidemic lineage of the ongoing seventh cholera pandemic.Competing Interest StatementThe authors have declared no competing interest.Footnotes* Minor revision of text for clarification; extension of discussion; new data shown in main Fig. 5, extended data, and supplementary Figure 1. | |
| 653 | |a Phages | ||
| 653 | |a Cholera | ||
| 653 | |a Prophylaxis | ||
| 653 | |a Pandemics | ||
| 653 | |a Epidemics | ||
| 653 | |a Genetic diversity | ||
| 653 | |a Vibrio cholerae | ||
| 700 | 1 | |a Jaskolska, Milena | |
| 700 | 1 | |a Lemopoulos, Alexandre | |
| 700 | 1 | |a Stutzmann, Sandrine | |
| 700 | 1 | |a Righi, Laurie | |
| 700 | 1 | |a Bader, Loriane | |
| 700 | 1 | |a Blokesch, Melanie | |
| 773 | 0 | |t bioRxiv |g (Jan 28, 2025) | |
| 786 | 0 | |d ProQuest |t Biological Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3132462547/abstract/embedded/J7RWLIQ9I3C9JK51?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3132462547/fulltextPDF/embedded/J7RWLIQ9I3C9JK51?source=fedsrch |
| 856 | 4 | 0 | |3 Full text outside of ProQuest |u https://www.biorxiv.org/content/10.1101/2024.11.23.624991v2 |