Therapeutic Potential of Bee and Wasp Venom in Anti-Arthritic Treatment: A Review

Guardado en:

Detalles Bibliográficos
Publicado en:	Toxins vol. 16, no. 11 (2024), p. 452
Autor principal:	Sun, Hongmei
Otros Autores:	Qu, Yunxia, Lei, Xiaojing, Xu, Qingzhu, Li, Siming, Shi, Zhengmei, Xiao, Huai, Zhang, Chenggui, Yang, Zhibin
Publicado:	MDPI AG
Materias:	Osteoarthritis Rheumatism Population Rheumatoid arthritis Rheumatic diseases Psoriasis Cytokines Bcl-2 protein BAX protein Remission (Medicine) NF-κB protein Inflammation Anti-inflammatory agents Etiology Quality of life Cell death TAK1 protein IRAK protein Apoptosis Steroids Osteoclastogenesis Arthritis Chronic pain Obesity Medical research Side effects Nonsteroidal anti-inflammatory drugs Venom Immunosuppressive agents Neuralgia Pathogenesis Psoriatic arthritis Bees Signal transduction Traditional medicine Social
Acceso en línea:	Citation/Abstract Full Text + Graphics Full Text - PDF
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

Descripción
Resumen:	Arthritis has a high global prevalence. During the early ancient human era, bee (Apis) venom therapy was employed in Egypt, Greece, and China to alleviate ailments such as arthritis and neuralgia. In addition, bee venom has long been used as a traditional medicine for immune-related diseases in Korea. Wasp (Vespa) venom is a folk medicine of the Jingpo people in Yunnan, China, and has been widely used to treat rheumatoid arthritis. In spite of this, the underlying mechanisms of bee and wasp venoms for the treatment of arthritis are yet to be fully understood. In recent years, researchers have investigated the potential anti-arthritic properties of bee and wasp venoms. Studies have shown that both bee and wasp venom can improve swelling, pain, and inflammation caused by arthritis. The difference is that bee venom reduces arthritis damage to bone and cartilage by inhibiting the IRAK2/TAK1/NF-κB signaling pathway, NF-κB signaling pathway, and JAK/STAT signaling pathway, as well as decreasing osteoclastogenesis by inhibiting the RANKL/RANK signaling pathway. Wasp venom, on the other hand, regulates synovial cell apoptosis via the Bax/Bcl-2 signaling pathway, inhibits the JAK/STAT signaling pathway to reduce inflammation production, and also ameliorates joint inflammation by regulating redox balance and iron death in synovial cells. This review provides a detailed overview of the various types of arthritis and their current therapeutic approaches; additionally, it comprehensively analyzes the therapeutic properties of bee venom, wasp venom, or venom components used as anti-arthritic drugs and explores their mechanisms of action in anti-arthritic therapy.
ISSN:	2072-6651
DOI:	10.3390/toxins16110452
Fuente:	Health & Medical Collection