Global RNA Virome in Wastewater Treatment Plants Reveals Ecological Insights and Human Health Implications
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| Gepubliceerd in: | bioRxiv (Jan 24, 2025) |
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| Andere auteurs: | , , , , |
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Cold Spring Harbor Laboratory Press
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| Online toegang: | Citation/Abstract Full text outside of ProQuest |
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|---|---|---|---|
| 001 | 3143454733 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2692-8205 | ||
| 024 | 7 | |a 10.1101/2024.03.12.584551 |2 doi | |
| 035 | |a 3143454733 | ||
| 045 | 0 | |b d20250124 | |
| 100 | 1 | |a Yuan, Ling | |
| 245 | 1 | |a Global RNA Virome in Wastewater Treatment Plants Reveals Ecological Insights and Human Health Implications | |
| 260 | |b Cold Spring Harbor Laboratory Press |c Jan 24, 2025 | ||
| 513 | |a Working Paper | ||
| 520 | 3 | |a RNA viruses are widely recognized for their roles in causing human diseases and shaping Earth's biodiversity. Wastewater treatment plants (WWTPs) are eco-friendly biotechnological systems where the roles of RNA viruses in process engineering and sanitation remain unclear. This study analyzed RNA sequencing dataset (> 3.8 Tb) from global WWTPs to examine the diversity, host associations, and auxiliary metabolic functions of RNA viruses. We identified 11,414 RNA virus operational taxonomic units (vOTUs), expanding the known diversity of RNA viruses in WWTPs by 67%. The RNA viral community in WWTPs was dominated by prokaryotic viruses, including both established RNA phage lineages and novel clades with broad ecological distributions, highlighting their underestimated diversity and broad niche breadths. Notably, a vOTU from the base-Howeltoviricetes phage clade was associated with the pathogenic bacterium Aliarcobacter cryaerophilus, suggesting potential applications in RNA phage therapy. Furthermore, the examined distribution and fate of human RNA viruses emphasized the utility of quantitative metatranscriptomics-based wastewater surveillance for public health monitoring. The discovery of auxiliary metabolic genes encoded by RNA viruses further revealed their involvement in critical host metabolic pathways such as translation and cellular respiration. These findings underscore the multifaceted roles of RNA viruses in the critical engineered systems.Competing Interest StatementThe authors have declared no competing interest.Footnotes* To imporve the quality of study, we further modified and updated the manuscript and figures.* https://github.com/emblab-westlake/WRVirDB | |
| 653 | |a Severe acute respiratory syndrome coronavirus 2 | ||
| 653 | |a Viruses | ||
| 653 | |a Process engineering | ||
| 653 | |a Rotavirus | ||
| 653 | |a Public health | ||
| 653 | |a Metabolism | ||
| 653 | |a RNA viruses | ||
| 653 | |a Metabolic pathways | ||
| 653 | |a Water treatment | ||
| 653 | |a RNA phages | ||
| 653 | |a Phages | ||
| 653 | |a Wastewater treatment | ||
| 653 | |a Sanitation | ||
| 700 | 1 | |a Chen, Linxing | |
| 700 | 1 | |a Yu, Hanqing | |
| 700 | 1 | |a Zhou, Jizhong | |
| 700 | 1 | |a Sun, Ren | |
| 700 | 1 | |a Ju, Feng | |
| 773 | 0 | |t bioRxiv |g (Jan 24, 2025) | |
| 786 | 0 | |d ProQuest |t Biological Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3143454733/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full text outside of ProQuest |u https://www.biorxiv.org/content/10.1101/2024.03.12.584551v3 |