The Aging Synapse: An Integrated Proteomic And Transcriptomic Analysis
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| Publicado no: | bioRxiv (Dec 20, 2024) |
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| Autor principal: | |
| Outros Autores: | , , , , , , , , , |
| Publicado em: |
Cold Spring Harbor Laboratory Press
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| Assuntos: | |
| Acesso em linha: | Citation/Abstract Full text outside of ProQuest |
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|---|---|---|---|
| 001 | 3147576530 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2692-8205 | ||
| 024 | 7 | |a 10.1101/2024.12.18.629115 |2 doi | |
| 035 | |a 3147576530 | ||
| 045 | 0 | |b d20241220 | |
| 100 | 1 | |a Caterino, Cinzia | |
| 245 | 1 | |a The Aging Synapse: An Integrated Proteomic And Transcriptomic Analysis | |
| 260 | |b Cold Spring Harbor Laboratory Press |c Dec 20, 2024 | ||
| 513 | |a Working Paper | ||
| 520 | 3 | |a An important hallmark of aging is the loss of proteostasis, which can lead to the formation of protein aggregates and mitochondrial dysfunction in neurons. Although it is well known that protein synthesis is finely regulated in the brain, especially at synapses, where mRNAs are locally translated in activity-dependent manner, little is known as to the changes in the synaptic proteome and transcriptome during aging. Therefore, this work aims to elucidate the relationship between transcriptome and proteome at soma and synaptic level during aging. Proteomic and transcriptomic data analysis reveal that, in young animals, proteins and transcripts are correlated and synaptic regulation is driven by changes in the soma. During aging, there is a decoupling between transcripts and proteins and between somatic and synaptic compartments. Furthermore, soma-synapse gradient of ribosomal genes changes upon aging, i.e. ribosomal transcripts are less abundant and ribosomal proteins are more abundant in synaptic compartment of old mice with respect to younglings. Additionally, transcriptomics data highlight a difference in the splicing of certain synaptic mRNA with aging. Taken together, our data provide a valuable resource for the study of the aging synapse.Competing Interest StatementThe authors have declared no competing interest. | |
| 653 | |a Transcriptomes | ||
| 653 | |a Proteomes | ||
| 653 | |a Transcriptomics | ||
| 653 | |a Ribosomal proteins | ||
| 653 | |a Protein biosynthesis | ||
| 653 | |a Aging | ||
| 653 | |a Synaptogenesis | ||
| 653 | |a Proteomics | ||
| 653 | |a Proteins | ||
| 700 | 1 | |a Ugolini, Martino | |
| 700 | 1 | |a Durso, William | |
| 700 | 1 | |a Jevdokimenko, Kristina | |
| 700 | 1 | |a Groth, Marco | |
| 700 | 1 | |a Riege, Konstantin | |
| 700 | 1 | |a Goerlach, Matthias | |
| 700 | 1 | |a Fornasiero, Eugenio | |
| 700 | 1 | |a Ori, Alessandro | |
| 700 | 1 | |a Hoffmann, Steve | |
| 700 | 1 | |a Cellerino, Alessandro | |
| 773 | 0 | |t bioRxiv |g (Dec 20, 2024) | |
| 786 | 0 | |d ProQuest |t Biological Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3147576530/abstract/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |
| 856 | 4 | 0 | |3 Full text outside of ProQuest |u https://www.biorxiv.org/content/10.1101/2024.12.18.629115v1 |