Metastasis of Rectal Signet Ring Cell Carcinoma to Typical Lipoma: A Rare Presentation of the Tumor-to-Tumor Metastasis Phenomenon

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Xehetasun bibliografikoak
Argitaratua izan da:Journal of Investigative Medicine High Impact Case Reports vol. 12 (Jan 2024)
Egile nagusia: Mansouri, Houyem
Beste egile batzuk: Zemni, Ines, Boujelbene, Nedia, Saadallah, Fatma, Mohamed Ali Ayadi, Achouri, Leila
Argitaratua:
Sage Publications Ltd.
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Sarrera elektronikoa:Citation/Abstract
Full text outside of ProQuest
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022 |a 2324-7096 
024 7 |a 10.1177/23247096241261309  |2 doi 
035 |a 3149766818 
045 2 |b d20240101  |b d20240131 
100 1 |a Mansouri, Houyem  |u Department of Surgical Oncology, Regional Hospital of Jendouba, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia 
245 1 |a Metastasis of Rectal Signet Ring Cell Carcinoma to Typical Lipoma: A Rare Presentation of the Tumor-to-Tumor Metastasis Phenomenon 
260 |b Sage Publications Ltd.  |c Jan 2024 
513 |a Journal Article 
520 3 |a Rectal signet ring cell carcinoma represents a rare subtype of colorectal adenocarcinoma known for its aggressive biological nature and poor prognosis. Although the co-occurrence of colorectal carcinoma with other tumors has been reported, the uncommon phenomenon of tumor-to-tumor metastasis, first described in 1930, remains rare. The most frequent donor neoplasms are lung or breast carcinomas, whereas cerebral meningiomas have been reported to be the most frequent recipient neoplasms. Here we report a case of a typical lipomatous tumor harboring metastatic signet ring cell rectal carcinoma. It is about a 42-year-old man diagnosed with rectal signet ring cell carcinoma and treated with concurrent radiotherapy and chemotherapy followed by an anterior resection and manual coloanal anastomosis with a temporary ileostomy. During the surgery, an abdominal wall lipoma was discovered and excised. A histopathological examination revealed infiltration of the fibro adipose tissue by a mucinous adenocarcinoma with a contingent of signet ring cells. The patient died 12 months after adjuvant chemotherapy due to peritoneal progression. To the best of our understanding, this represents the initial documented instance of tumor-to-tumor metastasis from rectal signet cell carcinoma to a conventional nonvascular lipoma. Consequently, even if one of these tumors appears clinically and radiologically benign, it is prudent to entertain the prospect of tumor-to-tumor metastasis. Thus, a comprehensive pathologic study of both tumors is highly recommended. 
653 |a Ostomy 
653 |a Cancer 
653 |a Metastasis 
653 |a Tumors 
653 |a Chemotherapy 
653 |a Brain cancer 
653 |a Breast cancer 
653 |a Colorectal cancer 
653 |a Radiation therapy 
700 1 |a Zemni, Ines  |u Department of Surgical Oncology, Salah Azaiez Institute, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia 
700 1 |a Boujelbene, Nedia  |u Department of Pathology, Salah Azaiez Institute, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia 
700 1 |a Saadallah, Fatma  |u Department of Surgical Oncology, Salah Azaiez Institute, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia 
700 1 |a Mohamed Ali Ayadi  |u Department of Surgical Oncology, Salah Azaiez Institute, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia 
700 1 |a Achouri, Leila  |u Department of Surgical Oncology, Regional Hospital of Jendouba, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia 
773 0 |t Journal of Investigative Medicine High Impact Case Reports  |g vol. 12 (Jan 2024) 
786 0 |d ProQuest  |t Health & Medical Collection 
856 4 1 |3 Citation/Abstract  |u https://www.proquest.com/docview/3149766818/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch 
856 4 0 |3 Full text outside of ProQuest  |u https://journals.sagepub.com/doi/10.1177/23247096241261309