Kinematics of abdominal aortic Aneurysms

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Publicat a:Journal of Biomechanics vol. 179 (Jan 2025)
Autor principal: Jamshidian, Mostafa
Altres autors: Wittek, Adam, Sekhavat, Saeideh, Miller, Karol
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Elsevier Limited
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024 7 |a 10.1016/j.jbiomech.2024.112484  |2 doi 
035 |a 3151842276 
045 2 |b d20250101  |b d20250131 
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100 1 |a Jamshidian, Mostafa 
245 1 |a Kinematics of abdominal aortic Aneurysms 
260 |b Elsevier Limited  |c Jan 2025 
513 |a Journal Article 
520 3 |a A search in Scopus within “Article title, Abstract, Keywords” unveils 2,444 documents focused on the biomechanics of Abdominal Aortic Aneurysm (AAA), mostly on AAA wall stress. Only 24 documents investigated AAA kinematics, an important topic that could potentially offer significant insights into the biomechanics of AAA. In this paper, we present an image-based approach for patient-specific, in vivo, and non-invasive AAA kinematic analysis using patient’s time-resolved 3D computed tomography angiography (4D-CTA) images, with an objective to measure wall displacement and strain during the cardiac cycle. Our approach relies on regularized deformable image registration for estimating wall displacement, estimation of the local wall strain as the ratio of its normal displacement to its local radius of curvature, and local surface fitting with non-deterministic outlier detection for estimating the wall radius of curvature. We verified our approach against synthetic ground truth image data created by warping a 3D-CTA image of AAA using a realistic displacement field obtained from a finite element biomechanical model. We applied our approach to assess AAA wall displacements and strains in ten patients. Our kinematic analysis results indicated that the 99th percentile of circumferential wall strain, among all patients, ranged from 2.62% to 5.54%, with an average of 4.45% and a standard deviation of 0.87%. We also observed that AAA wall strains are significantly lower than those of a healthy aorta. Our work demonstrates that the registration-based measurement of AAA wall displacements in the direction normal to the wall is sufficiently accurate to reliably estimate strain from these displacements. 
653 |a Outliers (statistics) 
653 |a Kinematics 
653 |a Formability 
653 |a Biomechanical engineering 
653 |a Aorta 
653 |a Asymptomatic 
653 |a Strain analysis 
653 |a Image registration 
653 |a Medical imaging 
653 |a Angiography 
653 |a Image processing 
653 |a Registration 
653 |a Cycle ratio 
653 |a In vivo methods and tests 
653 |a Radius of curvature 
653 |a Patients 
653 |a Data analysis 
653 |a Aortic aneurysms 
653 |a Biomechanics 
653 |a Computed tomography 
653 |a Aneurysms 
653 |a Documents 
653 |a Mechanical properties 
653 |a Estimation 
653 |a Tomography 
653 |a Finite element analysis 
700 1 |a Wittek, Adam 
700 1 |a Sekhavat, Saeideh 
700 1 |a Miller, Karol 
773 0 |t Journal of Biomechanics  |g vol. 179 (Jan 2025) 
786 0 |d ProQuest  |t Health & Medical Collection 
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856 4 0 |3 Full Text  |u https://www.proquest.com/docview/3151842276/fulltext/embedded/6A8EOT78XXH2IG52?source=fedsrch 
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