Locally induced traveling waves generate globally observable traveling waves
Shranjeno v:
| izdano v: | bioRxiv (Jan 7, 2025) |
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| Glavni avtor: | |
| Drugi avtorji: | , |
| Izdano: |
Cold Spring Harbor Laboratory Press
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| Teme: | |
| Online dostop: | Citation/Abstract Full text outside of ProQuest |
| Oznake: |
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| LEADER | 00000nab a2200000uu 4500 | ||
|---|---|---|---|
| 001 | 3152304875 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2692-8205 | ||
| 024 | 7 | |a 10.1101/2025.01.07.630662 |2 doi | |
| 035 | |a 3152304875 | ||
| 045 | 0 | |b d20250107 | |
| 100 | 1 | |a Petras, Kirsten | |
| 245 | 1 | |a Locally induced traveling waves generate globally observable traveling waves | |
| 260 | |b Cold Spring Harbor Laboratory Press |c Jan 7, 2025 | ||
| 513 | |a Working Paper | ||
| 520 | 3 | |a Cortical traveling waves have been proposed as a fundamental mechanism for neural communication and computation. Methodological uncertainties currently limit the interpretability of non-invasive, extracranial traveling wave data, sparking debates about their cortical origin. Studies using EEG or MEG typically report waves that cover large portions of the sensor array which are often interpreted as reflecting long range cortical waves. Meanwhile, invasive, intracranial recordings in humans and animals routinely find both local, mesoscopic waves and large scale, macroscopic waves in cortex. Whether the global sensor-array waves found with EEG/MEG necessarily correspond to macroscopic cortical waves or whether they are merely projections of local dynamics remains unclear. In this study, we made use of the well-established retinotopic organization of early visual cortex to generate traveling waves with known properties in human participants (N=19, m/f) via targeted visual stimulation, while simultaneously recording MEG and EEG. The inducer stimuli were designed to elicit waves whose traveling direction in mesoscopic retinotopic visual areas depends on stimulus direction, while leaving macroscopic activation patterns along the visual hierarchy largely unchanged. We observed that the preferred direction of traveling waves across the sensor array was influenced by that of the visual stimulus, but only at the stimulation frequency. Comparison between single-trial and trial-averaged responses further showed considerable temporal variation in traveling wave patterns across trials. Our results highlight that under tight experimental control, non-invasive, extracranial recordings can recover mesoscopic traveling wave activity, thus making them viable tools for the investigation of spatially constrained wave dynamics.Competing Interest StatementThe authors have declared no competing interest. | |
| 653 | |a Retina | ||
| 653 | |a Visual pathways | ||
| 653 | |a Visual cortex | ||
| 653 | |a Temporal variations | ||
| 653 | |a Information processing | ||
| 653 | |a Visual stimuli | ||
| 653 | |a EEG | ||
| 653 | |a Temporal lobe | ||
| 653 | |a Sensors | ||
| 700 | 1 | |a Grabot, Laetitia | |
| 700 | 1 | |a Dugué, Laura | |
| 773 | 0 | |t bioRxiv |g (Jan 7, 2025) | |
| 786 | 0 | |d ProQuest |t Biological Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3152304875/abstract/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |
| 856 | 4 | 0 | |3 Full text outside of ProQuest |u https://www.biorxiv.org/content/10.1101/2025.01.07.630662v1 |