Distinct origin and fate for fetal hematopoietic progenitors
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| Publicado en: | bioRxiv (Jan 9, 2025) |
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| Autor principal: | |
| Otros Autores: | , , , , , , , , , , |
| Publicado: |
Cold Spring Harbor Laboratory Press
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| Acceso en línea: | Citation/Abstract Full Text - PDF Full text outside of ProQuest |
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| 001 | 3153303237 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2692-8205 | ||
| 024 | 7 | |a 10.1101/2025.01.08.631951 |2 doi | |
| 035 | |a 3153303237 | ||
| 045 | 0 | |b d20250109 | |
| 100 | 1 | |a Soares-Da-Silva, Francisca | |
| 245 | 1 | |a Distinct origin and fate for fetal hematopoietic progenitors | |
| 260 | |b Cold Spring Harbor Laboratory Press |c Jan 9, 2025 | ||
| 513 | |a Working Paper | ||
| 520 | 3 | |a It was proposed that two sequential sources of intraembryonic multipotent progenitors ensure blood cell production from late gestation into adulthood, with only the latter producing self-renewing hematopoietic stem cells (HSC). How these two populations differ and how they impact the establishment of the postnatal immune system, remains poorly understood. Using complementary lineage tracing models, we showed that the first emerging embryonic multipotent progenitors (eMPP) are responsible for late gestation hematopoiesis. They are distinct from HSC that do not significantly contribute to embryonic mature blood cells. eMPP are the predominant source of embryonic lymphocytes and lymphoid tissue inducer cells, some of which persist for life. Between E12.5 and E16.5 eMPP rapidly differentiate, whereas HSC expand 20-fold. Altogether, these results support the notion that eMPP establish the embryonic adaptive immune system and shape the lymphoid organs where later adaptive immune responses occur, while HSC expand to sustain blood cell production throughout life.Competing Interest StatementThe authors have declared no competing interest. | |
| 653 | |a Hematopoietic stem cells | ||
| 653 | |a Cell differentiation | ||
| 653 | |a Hemopoiesis | ||
| 653 | |a Progenitor cells | ||
| 653 | |a Blood | ||
| 653 | |a Lymphocytes | ||
| 653 | |a Immune system | ||
| 653 | |a Gestation | ||
| 653 | |a Blood cells | ||
| 653 | |a Fetuses | ||
| 653 | |a Lymphoid tissue | ||
| 653 | |a Immune response | ||
| 700 | 1 | |a Nogueira, Gonçalo | |
| 700 | 1 | |a Marie-Pierre Mailhe | |
| 700 | 1 | |a Freyer, Laina | |
| 700 | 1 | |a Perkins, Archibald | |
| 700 | 1 | |a Hatano, Shinya | |
| 700 | 1 | |a Yoshikai, Yasunobu | |
| 700 | 1 | |a Pereira, Pablo | |
| 700 | 1 | |a Bandeira, Antonio | |
| 700 | 1 | |a Elsaid, Ramy | |
| 700 | 1 | |a Gomez-Perdiguero, Elisa | |
| 700 | 1 | |a Cumano, Ana | |
| 773 | 0 | |t bioRxiv |g (Jan 9, 2025) | |
| 786 | 0 | |d ProQuest |t Biological Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3153303237/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3153303237/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full text outside of ProQuest |u https://www.biorxiv.org/content/10.1101/2025.01.08.631951v1 |