The effect of additive biomaterials on the printability and characterization of PCL-based composite scaffolds fabricated by screw extrusion 3D printing
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| Yayımlandı: | Materials Research Express vol. 12, no. 1 (Jan 2025), p. 015401 |
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| Yazar: | |
| Diğer Yazarlar: | , , , |
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IOP Publishing
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| Konular: | |
| Online Erişim: | Citation/Abstract Full Text - PDF |
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MARC
| LEADER | 00000nab a2200000uu 4500 | ||
|---|---|---|---|
| 001 | 3155709669 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2053-1591 | ||
| 024 | 7 | |a 10.1088/2053-1591/ada5bd |2 doi | |
| 035 | |a 3155709669 | ||
| 045 | 2 | |b d20250101 |b d20250131 | |
| 100 | 1 | |a Phung, Lan Xuan |u School of Mechanical Engineering, Hanoi University of Science and Technology , Hanoi, Vietnam | |
| 245 | 1 | |a The effect of additive biomaterials on the printability and characterization of PCL-based composite scaffolds fabricated by screw extrusion 3D printing | |
| 260 | |b IOP Publishing |c Jan 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a To enhance cell adhesion and cell interactions for diverse tissue engineering applications, polycaprolactone (PCL) has been integrated with few biomaterials such as ceramic (i.e. tricalcium phosphate - TCP), hydrogel (i.e. sodium alginate - SA), and synthetic polymer materials (i.e. polyethylene glycol - PEG). Each type of additive material presents typical characteristics, the comparison among these three biomaterial types is currently inadequate. In this study, a 3D printer using direct powder screw extrusion technique was applied for fabricating three types of PCL-based composite scaffolds (namely, PCL-PEG, PCL-SA, and PCL-TCP) which are representative of each type of additive material. The experimental evaluation on the printability, scaffold morphology, surface roughness, hydrophobicity, and cell proliferation of these PCL-based composite scaffolds were compared under the same conditions. The results demonstrated that the additive materials with an amount from 20 wt% have a notable effect on the printability of PCL matrix material and significant enhancement of cell proliferation. The incorporation of PEG with PCL is the most effective choice to increase the hydrophilicity of the scaffold surface. The PCL-SA scaffold provided a more favorable environment for cells at the initial stage, whereas the PCL-TCP scaffold demonstrated superior cell proliferation over time. These findings also demonstrate the feasibility of a direct powder screw extrusion printhead on 3D printing for composite scaffolds in tissue engineering applications. | |
| 653 | |a Tissue engineering | ||
| 653 | |a Printers (data processing) | ||
| 653 | |a Calcium phosphates | ||
| 653 | |a Biomedical materials | ||
| 653 | |a Hydrophobicity | ||
| 653 | |a Polycaprolactone | ||
| 653 | |a 3-D printers | ||
| 653 | |a Cell adhesion | ||
| 653 | |a Surface roughness | ||
| 653 | |a Three dimensional printing | ||
| 653 | |a Scaffolds | ||
| 653 | |a Cell growth | ||
| 653 | |a Sodium alginate | ||
| 653 | |a Polyethylene glycol | ||
| 653 | |a Three dimensional composites | ||
| 653 | |a Extrusion | ||
| 700 | 1 | |a Bang Thi Le |u School of Materials Science and Engineering, Hanoi University of Science and Technology , Hanoi, Vietnam | |
| 700 | 1 | |a Phuong Mai Thi Nguyen |u Institute of Biotechnology , Vietnam Academy of Science and Technology, Hanoi, Vietnam | |
| 700 | 1 | |a Huyen Trang Thi Nguyen |u Department of Life Sciences, University of Science and Technology of Hanoi , Vietnam Academy of Science and Technology, Hanoi, Vietnam | |
| 700 | 1 | |a Trung Kien Nguyen |u School of Mechanical Engineering, Hanoi University of Science and Technology , Hanoi, Vietnam | |
| 773 | 0 | |t Materials Research Express |g vol. 12, no. 1 (Jan 2025), p. 015401 | |
| 786 | 0 | |d ProQuest |t Materials Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3155709669/abstract/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3155709669/fulltextPDF/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |