Redundant, weakly connected prefrontal hemispheres balance precision and capacity in spatial working memory
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| Publikašuvnnas: | bioRxiv (Jan 16, 2025) |
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| Váldodahkki: | |
| Eará dahkkit: | , , , , |
| Almmustuhtton: |
Cold Spring Harbor Laboratory Press
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| Fáttát: | |
| Liŋkkat: | Citation/Abstract Full text outside of ProQuest |
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| LEADER | 00000nab a2200000uu 4500 | ||
|---|---|---|---|
| 001 | 3156258836 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2692-8205 | ||
| 024 | 7 | |a 10.1101/2025.01.15.633176 |2 doi | |
| 035 | |a 3156258836 | ||
| 045 | 0 | |b d20250116 | |
| 100 | 1 | |a Tschiersch, Melanie | |
| 245 | 1 | |a Redundant, weakly connected prefrontal hemispheres balance precision and capacity in spatial working memory | |
| 260 | |b Cold Spring Harbor Laboratory Press |c Jan 16, 2025 | ||
| 513 | |a Working Paper | ||
| 520 | 3 | |a How the prefrontal hemispheres coordinate to adapt to spatial working memory (WM) demands remains an open question. Recently, two models have been proposed: A specialized model, where each hemisphere governs contralateral behavior, and a redundant model, where both hemispheres equally guide behavior in the full visual space. To explore these alternatives, we analyzed simultaneous bilateral prefrontal cortex recordings from three macaque monkeys performing a visuo-spatial WM task. Each hemisphere represented targets across the full visual field and equally predicted behavioral imprecisions. Furthermore, memory errors were weakly correlated between hemispheres, suggesting that redundant, weakly coupled prefrontal hemispheres support spatial WM. Attractor model simulations showed that the hemispheric redundancy improved precision in simple tasks, whereas weak inter-hemispheric coupling allowed for specialized hemispheres in complex tasks. This interhemispheric architecture reconciles previous findings thought to support distinct models into a unified architecture, providing a versatile interhemispheric architecture that adapts to varying cognitive demands.Competing Interest StatementThe authors have declared no competing interest. | |
| 653 | |a Mental task performance | ||
| 653 | |a Memory | ||
| 653 | |a Visual field | ||
| 653 | |a Cerebral hemispheres | ||
| 653 | |a Spatial memory | ||
| 653 | |a Short term memory | ||
| 653 | |a Prefrontal cortex | ||
| 700 | 1 | |a Umakantha, Akash | |
| 700 | 1 | |a Williamson, Ryan C | |
| 700 | 1 | |a Smith, Matthew A | |
| 700 | 1 | |a Barbosa, Joao | |
| 700 | 1 | |a Compte, Albert | |
| 773 | 0 | |t bioRxiv |g (Jan 16, 2025) | |
| 786 | 0 | |d ProQuest |t Biological Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3156258836/abstract/embedded/ZKJTFFSVAI7CB62C?source=fedsrch |
| 856 | 4 | 0 | |3 Full text outside of ProQuest |u https://www.biorxiv.org/content/10.1101/2025.01.15.633176v1 |