Differential effects of conventional transcranial direct current stimulation (tDCS) and high-definition transcranial direct current stimulation (HD-tDCS) of the cerebellum on offset analgesia
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| Publicado en: | bioRxiv (Jan 28, 2025) |
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| Otros Autores: | , , , , |
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Cold Spring Harbor Laboratory Press
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| Acceso en línea: | Citation/Abstract Full text outside of ProQuest |
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| 001 | 3157049015 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2692-8205 | ||
| 024 | 7 | |a 10.1101/2024.10.03.616281 |2 doi | |
| 035 | |a 3157049015 | ||
| 045 | 0 | |b d20250128 | |
| 100 | 1 | |a O'connor, Niamh | |
| 245 | 1 | |a Differential effects of conventional transcranial direct current stimulation (tDCS) and high-definition transcranial direct current stimulation (HD-tDCS) of the cerebellum on offset analgesia | |
| 260 | |b Cold Spring Harbor Laboratory Press |c Jan 28, 2025 | ||
| 513 | |a Working Paper | ||
| 520 | 3 | |a Background: Offset analgesia (OA) describes the large decrease in perceived pain in response to a minor decrease in applied painful thermal stimulus. Here non-invasive brain stimulation (NIBS) is used to modulate the cerebellum, since the cerebellum is known to signal sensory prediction errors and implicated in pain processing. Methods: An OA protocol individualized to heat pain threshold (HPT) was applied via TSA-II (Medoc, Israel). NIBS interventions were applied prior to OA. Cathodal cerebellar transcranial direct current stimulation (tDCS) and high-definition (4X1) transcranial direct current stimulation (HD-tDCS) were applied to 46 healthy participants within a sham controlled repeated measures design to examine whether diffuse or focal stimulation differentially modulates OA. Results: OA induced hypoalgesia was robust, with 90% of responses showing a drop in perceived pain (δVAS) > 10 following the 1°C fall in temperature. This OA response was augmented following a protocol with sham and focal cathodal cerebellar stimulation on four OA parameters (OA latency, VAS minimum, VAS mean and VAS 2nd max) relative to pre-stimulation. This effect was differential to the protocol with sham and conventional tDCS where two OA metrics altered (OA duration, VAS 2nd max). Conclusion: OA enhancement via cathodal cerebellar NIBS may involve both a placebo effect and sustaining a noxious sensory prediction error. Understanding how the cerebellum is involved in OA could enhance therapies for pain patients.Competing Interest StatementThe authors have declared no competing interest.Footnotes* There are updates to the introduction, including missing references | |
| 653 | |a Signal processing | ||
| 653 | |a Pain | ||
| 653 | |a Cerebellum | ||
| 653 | |a Information processing | ||
| 653 | |a Latency | ||
| 653 | |a Electrical stimulation of the brain--ESB | ||
| 653 | |a Sensory integration | ||
| 653 | |a Analgesia | ||
| 653 | |a Placebos | ||
| 653 | |a Pain perception | ||
| 700 | 1 | |a Ashe, Hannah | |
| 700 | 1 | |a Wragan, Max | |
| 700 | 1 | |a O'flaherty, Ruairi | |
| 700 | 1 | |a Deevy-Gray, Eoin | |
| 700 | 1 | |a Witney, Alice G | |
| 773 | 0 | |t bioRxiv |g (Jan 28, 2025) | |
| 786 | 0 | |d ProQuest |t Biological Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3157049015/abstract/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |
| 856 | 4 | 0 | |3 Full text outside of ProQuest |u https://www.biorxiv.org/content/10.1101/2024.10.03.616281v3 |