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Seroprevalence of TORCH Viral Agents in Pregnant Women in Turkey: Systematic Review and Meta-Analysis

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Yayımlandı:Pathogens vol. 14, no. 1 (2025), p. 37
Yazar: Elmas Pinar Kahraman Kilbas
Diğer Yazarlar: Ciftci, Ihsan Hakki, Kilbas, Imdat, Toptan, Hande
Baskı/Yayın Bilgisi:
MDPI AG
Konular:
Turkey
United States > US
Hepatitis B
Zika virus
Hepatitis C
Hygiene
Asymptomatic
Rubella
Herpes simplex
Public awareness
Miscarriage
Data analysis
Heterogeneity
Quality control
Hepatitis
Statistical methods
Meta-analysis
Vaccination
Infections
Software
Pathogens
Womens health
Pregnancy
Congenital diseases
Serology
Industrialized nations
Statistical analysis
Chronology
Fetuses
Human immunodeficiency virus > HIV
Publications
Cytomegalovirus
Diagnostic systems
Viral infections
Babies
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Özet:Rubella Virus, Cytomegalovirus (CMV), Herpes Simplex Virus-2 (HSV-2), Hepatitis B (HBV) and Hepatitis C virus (HCV) can cause serious fetal disease. The seropositivity rates of these agents vary among countries and geographic regions. This study aimed to analyze the prevalence rates and diagnostic methods used in studies investigating the seroprevalence of viral pathogens in the TORCH group among pregnant women in Turkey between 2005 and 2024. A systematic search was conducted using electronic databases between January 2005 and January 2024. A total of 60 studies meeting the inclusion criteria were included. Data quality control was assessed using the Joanna Briggs Institute guideline prevalence studies checklist. Heterogeneity was measured using the I-squared (I2) statistic in the Comprehensive Meta Analysis (CMA) program. The average seropositivity rates for Rubella, CMV, HSV-2, HBV and HCV in Turkey were determined as 91.18%, 94.81%, 35.52%, 1.66% and 0.25%, respectively. When the diagnostic methods were examined, it was determined that ELISA and ECLIA methods were used most frequently. The seropositivity of the agents did not show statistically significant differences according to the year periods, geographical regions and age of the patients (p > 0.05). The highest prevalence rates of Rubella and HSV-2 in pregnant women were reported in the Mediterranean region, the highest prevalence rates of CMV and HCV in the Southeastern Anatolia region and the highest seroprevalence of Anti HBs in the Marmara region. The results of this study support the necessity of increasing public awareness in the control of fetal infection caused by TORCH viral agents, prenatal screening, vaccination for Rubella and HBV and compliance with hygiene conditions for agents such as CMV, HSV-2 and HCV. The results of this study highlight the need to increase public awareness on prenatal screening for the control of fetal infection caused by all TORCH viral agents, vaccination for Rubella and HBV and compliance with hygiene conditions for agents such as CMV, HSV-2 and HCV.
ISSN:2076-0817
DOI:10.3390/pathogens14010037
Kaynak:Biological Science Database