Synaptome architecture shapes regional dynamics in the mouse brain
-д хадгалсан:
| -д хэвлэсэн: | bioRxiv (Jan 25, 2025) |
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| Үндсэн зохиолч: | |
| Бусад зохиолчид: | , , , , , , |
| Хэвлэсэн: |
Cold Spring Harbor Laboratory Press
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| Нөхцлүүд: | |
| Онлайн хандалт: | Citation/Abstract Full Text - PDF Full text outside of ProQuest |
| Шошгууд: |
Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!
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MARC
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| 001 | 3159711641 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2692-8205 | ||
| 024 | 7 | |a 10.1101/2025.01.24.634803 |2 doi | |
| 035 | |a 3159711641 | ||
| 045 | 0 | |b d20250125 | |
| 100 | 1 | |a Hansen, Justine Y | |
| 245 | 1 | |a Synaptome architecture shapes regional dynamics in the mouse brain | |
| 260 | |b Cold Spring Harbor Laboratory Press |c Jan 25, 2025 | ||
| 513 | |a Working Paper | ||
| 520 | 3 | |a Synapses are the connections that transform neurons from simple electrically charged cells into complex circuits that support perception, cognition and action. Recent advances in single-punctum synapse mapping in mice have made it possible to study the diversity of synapses and how these synapse types are differentially expressed across the brain. A salient question is how synapse diversity shapes the spatial patterning of whole-brain dynamics. Here we derive >6,000 time-series features from fMRI recordings in awake mice to construct a comprehensive macroscale dynamical phenotype of each synapse type. We find that spatial variation in synapse types colocalizes with spatial variation in regional dynamics. Time-series in regions enriched for SAP102-expressing synapses display high-amplitude events while time-series in regions enriched for PSD95-expressing synapses display low stationarity. These regional variations in synapse types and dynamics are associated with patterns of structural and functional connectivity and the placement of hubs. Finally, using two additional fMRI datasets in anaesthetized mice, we show that synapses expressing short- and long-lifetime proteins are differentially engaged across behavioural states. Collectively, this work demonstrates that the spatial organization of microscale synapse types fundamentally shapes whole-brain dynamics.Competing Interest StatementThe authors have declared no competing interest.Footnotes* https://github.com/netneurolab/hansen_synaptome | |
| 653 | |a Brain architecture | ||
| 653 | |a Cognition | ||
| 653 | |a Spatial variations | ||
| 653 | |a Functional magnetic resonance imaging | ||
| 653 | |a Phenotypic variations | ||
| 653 | |a Postsynaptic density proteins | ||
| 653 | |a Structure-function relationships | ||
| 653 | |a Pattern formation | ||
| 653 | |a Synapses | ||
| 653 | |a Time series | ||
| 653 | |a Neural networks | ||
| 653 | |a Phenotypes | ||
| 653 | |a Brain mapping | ||
| 700 | 1 | |a Luppi, Andrea I | |
| 700 | 1 | |a Qiu, Zhen | |
| 700 | 1 | |a Gini, Silvia | |
| 700 | 1 | |a Fulcher, Ben D | |
| 700 | 1 | |a Gozzi, Alessandro | |
| 700 | 1 | |a Grant, Seth Gn | |
| 700 | 1 | |a Misic, Bratislav | |
| 773 | 0 | |t bioRxiv |g (Jan 25, 2025) | |
| 786 | 0 | |d ProQuest |t Biological Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3159711641/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3159711641/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full text outside of ProQuest |u https://www.biorxiv.org/content/10.1101/2025.01.24.634803v1 |