Fisher Information and the Dynamics of Multicellular Aging
Guardado en:
| Publicado en: | bioRxiv (Jan 27, 2025) |
|---|---|
| Autor principal: | |
| Otros Autores: | , |
| Publicado: |
Cold Spring Harbor Laboratory Press
|
| Materias: | |
| Acceso en línea: | Citation/Abstract Full Text - PDF Full text outside of ProQuest |
| Etiquetas: |
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Resumen: | Information theory has long been integrated into the study of biological aging, for example in examining the roles of genetic and epigenetic fidelity in cellular and organismal longevity. Here, we introduce a theoretical model that interprets aging in multicellular systems through the lens of Fisher information. Previous theories have suggested that the aging of multicellular organisms is an inevitable consequence of the inherent tension between individual cell reproduction and the homeostasis of the multicellular system. Utilizing concepts from information theory and statistical mechanics, we show that Fisher information parametrizes the dynamics of this tension through non-monotonic behaviour which depends on an optimal balance of competition and cooperation between cells. Moreover, Fisher information suggests that the ability to infer true biological age from a sample evolves through complex dynamics over an organisms lifespan.Competing Interest StatementThe authors have declared no competing interest. |
|---|---|
| ISSN: | 2692-8205 |
| DOI: | 10.1101/2025.01.24.634675 |
| Fuente: | Biological Science Database |