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Mitochondrial dysfunction underlies monocyte immune deficiency in patients with severe alcohol-related hepatitis

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Publicado en:bioRxiv (Jan 29, 2025)
Autor principal: Middleton, Paul K
Otros Autores: Aramayo, Ricardo J, Montoya, Alex, Shliaha, Pavel V, Pope, Simon, Fets, Louise, Vergis, Nikhil, Thursz, Mark R, Cochemé, Helena M
Publicado:
Cold Spring Harbor Laboratory Press
Materias:
Cardiolipin
Monocytes
Liver diseases
Structure-function relationships
Mortality
Mitochondria
Structural proteins
Cristae
Ultrastructure
Hepatitis
Immune response
Acceso en línea:Citation/Abstract
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Resumen:Severe alcohol-related hepatitis (sAH) is a life-threatening form of alcohol-related liver disease (ARLD) associated with a significant short-term mortality. Opportunistic infections due to impaired immune function are a major cause of patient mortality. Mitochondrial dysfunction within the liver is a well-recognised feature of ARLD and sAH. However, whether these hepatic mitochondrial defects extend to the immune system of sAH patients, underlying their immune dysfunction, remains unclear. Here, we demonstrate that sAH monocytes exhibit an increased content of inefficient, dysfunctional mitochondria. These changes were underpinned by abnormal mitochondrial cristae ultrastructure, which were associated with depletion of cristae structural proteins and alterations in cardiolipin profiles. Overall, our study uncovers novel structural and functional mitochondrial defects, which likely contribute to impaired monocyte immune function in sAH.Competing Interest StatementThe authors have declared no competing interest.
ISSN:2692-8205
DOI:10.1101/2025.01.28.634915
Fuente:Biological Science Database