Azala

Disruption of transthalamic circuitry from primary visual cortex impairs visual discrimination in mice

Gorde:
Argitaratua izan da:bioRxiv (Feb 8, 2025)
Egile nagusia: Mckinnon, Claire
Beste egile batzuk: Mo, Christina, S Murray Sherman
Argitaratua:
Cold Spring Harbor Laboratory Press
Gaiak:
Signal processing
Somatosensory cortex
Visual perception
Thalamic nuclei
Visual system
Pulvinar
Visual pathways
Visual cortex
Cell interactions
Information processing
Visual stimuli
Sensory integration
Visual discrimination
Decision making
Thalamus
Circuits
Sarrera elektronikoa:Citation/Abstract
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Laburpena:Layer 5 (L5) of the cortex provides strong driving input to higher-order thalamic nuclei, such as the pulvinar in the visual system, forming the basis of cortico-thalamo-cortical (transthalamic) circuits. These circuits provide a communication route between cortical areas in parallel to direct corticocortical connections, but their specific role in perception and behavior remains unclear. Using targeted optogenetic inhibition in mice performing a visual discrimination task, we selectively suppressed the corticothalamic input from L5 cells in primary visual cortex (V1) at their terminals in pulvinar. This suppresses transthalamic circuits from V1; furthermore, any effect on direct corticocortical projections and local V1 circuitry would thus result from transthalamic inputs (e.g., V1 to pulvinar back to V1 (Miller-Hansen and Sherman, 2022). Such suppression of transthalamic processing during visual stimulus presentation of drifting gratings significantly impaired discrimination performance across different orientations. The impact on behavior was specific to the portion of visual space that retinotopically coincided with the V1 L5 corticothalamic inhibition. These results highlight the importance of incorporating L5-initiated transthalamic circuits into cortical processing frameworks, particularly those addressing how the hierarchical propagation of sensory signals supports perceptual decision-making.Competing Interest StatementThe authors have declared no competing interest.
ISSN:2692-8205
DOI:10.1101/2025.02.07.637190
Baliabidea:Biological Science Database