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Spatial Transcriptomics in Human Cardiac Tissue

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發表在:International Journal of Molecular Sciences vol. 26, no. 3 (2025), p. 995
主要作者: Nguyen, Quynh
其他作者: Lin, Wei Tung, Lin, Bruce, Sivakumar, Raam, Sar, Funda, Singhera, Gurpreet, Wang, Ying, Parker, Jeremy, Stephane Le Bihan, Singh, Amrit, Rossi, Fabio MV, Collins, Colin, Bashir, Jamil, Laksman, Zachary
出版:
MDPI AG
主題:
Hybridization
Physiology
Gene expression
Tissues
Genomics
Disease
Cardiac function
Bar codes
Technology
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Resumen:Spatial transcriptomics has transformed our understanding of gene expression by preserving the spatial context within tissues. This review focuses on the application of spatial transcriptomics in human cardiac tissues, exploring current technologies with a focus on commercially available platforms. We also highlight key studies utilizing spatial transcriptomics to investigate cardiac development, electro-anatomy, immunology, and ischemic heart disease. These studies demonstrate how spatial transcriptomics can be used in conjunction with other omics technologies to provide a more comprehensive picture of human health and disease. Despite its transformative potential, spatial transcriptomics comes with several challenges that limit its widespread adoption and broader application. By addressing these limitations and fostering interdisciplinary collaboration, spatial transcriptomics has the potential to become an essential tool in cardiovascular research. We hope this review serves as a practical guide for researchers interested in adopting spatial transcriptomics, particularly those with limited prior experience, by providing insights into current technologies, applications, and considerations for successful implementation.
ISSN:1661-6596
1422-0067
DOI:10.3390/ijms26030995
Fuente:Health & Medical Collection