Perception and neural representation of intermittent odor stimuli in mice
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| Publicado en: | bioRxiv (Feb 13, 2025) |
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| Otros Autores: | , , , , , , , |
| Publicado: |
Cold Spring Harbor Laboratory Press
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| Acceso en línea: | Citation/Abstract Full text outside of ProQuest |
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| 001 | 3166351696 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2692-8205 | ||
| 024 | 7 | |a 10.1101/2025.02.12.637969 |2 doi | |
| 035 | |a 3166351696 | ||
| 045 | 0 | |b d20250213 | |
| 100 | 1 | |a Boero, Luis E | |
| 245 | 1 | |a Perception and neural representation of intermittent odor stimuli in mice | |
| 260 | |b Cold Spring Harbor Laboratory Press |c Feb 13, 2025 | ||
| 513 | |a Working Paper | ||
| 520 | 3 | |a Odor cues in nature are sparse and highly fluctuating due to turbulent transport. To investigate how animals perceive these intermittent cues, we developed a behavioral task in which head-restrained mice made binary decisions based on the total number of discrete odor pulses presented stochastically over several seconds. Mice readily learned this task, and their performance was well-described by widely used decision models. Logistic regression of binary choices against the timing of odor pulses within the respiratory cycle revealed that mice placed higher perceptual weight to stimuli arriving during inhalation than exhalation, a phase dependency that strongly correlated with the magnitude of responses in olfactory sensory neurons. The population response of anterior piriform cortex (APCx) neurons to odor pulses was also modulated by respiration phase, although individual neurons displayed varying levels of phase-dependence. Single APCx neurons responded stochastically and transiently to odor pulses, leading to a representation that carries signatures of sensory evidence, but not its accumulation. Our study reveals that mice can integrate intermittent odor signals across dozens of breaths, but respiratory modulation of sensory inputs imposes limits on information acquisition that cortical circuits cannot overcome to improve behavior.Competing Interest StatementThe authors have declared no competing interest. | |
| 653 | |a Somatosensory cortex | ||
| 653 | |a Sensory evaluation | ||
| 653 | |a Chemical stimuli | ||
| 653 | |a Regression analysis | ||
| 653 | |a Odors | ||
| 653 | |a Olfactory receptor neurons | ||
| 653 | |a Mental task performance | ||
| 653 | |a Sensory neurons | ||
| 653 | |a Cortex (olfactory) | ||
| 653 | |a Information processing | ||
| 653 | |a Piriform cortex | ||
| 653 | |a Olfactory pathways | ||
| 653 | |a Inhalation | ||
| 653 | |a Animal models | ||
| 653 | |a Olfactory stimuli | ||
| 653 | |a Odor | ||
| 653 | |a Decision making | ||
| 653 | |a Neural coding | ||
| 700 | 1 | |a Wu, Hao | |
| 700 | 1 | |a Zak, Joseph D | |
| 700 | 1 | |a Masset, Paul | |
| 700 | 1 | |a Pashakhanloo, Farhad | |
| 700 | 1 | |a Jayakumar, Siddharth | |
| 700 | 1 | |a Tolooshams, Bahareh | |
| 700 | 1 | |a Demba Ba | |
| 700 | 1 | |a Murthy, Venkatesh N | |
| 773 | 0 | |t bioRxiv |g (Feb 13, 2025) | |
| 786 | 0 | |d ProQuest |t Biological Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3166351696/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full text outside of ProQuest |u https://www.biorxiv.org/content/10.1101/2025.02.12.637969v1 |