Distinct Neural Representations of Hunger and Thirst in Neonatal Mice before the Emergence of Food- and Water-seeking Behaviors
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| Publicado en: | bioRxiv (Feb 13, 2025) |
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| Otros Autores: | , , , , , |
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Cold Spring Harbor Laboratory Press
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| Acceso en línea: | Citation/Abstract Full text outside of ProQuest |
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| LEADER | 00000nab a2200000uu 4500 | ||
|---|---|---|---|
| 001 | 3166351725 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2692-8205 | ||
| 024 | 7 | |a 10.1101/2024.09.22.614378 |2 doi | |
| 035 | |a 3166351725 | ||
| 045 | 0 | |b d20250213 | |
| 100 | 1 | |a Wang, David C | |
| 245 | 1 | |a Distinct Neural Representations of Hunger and Thirst in Neonatal Mice before the Emergence of Food- and Water-seeking Behaviors | |
| 260 | |b Cold Spring Harbor Laboratory Press |c Feb 13, 2025 | ||
| 513 | |a Working Paper | ||
| 520 | 3 | |a Hunger and thirst are two fundamental drives for maintaining homeostasis and elicit distinct food- and water-seeking behaviors essential for survival. For neonatal mammals, however, both hunger and thirst are sated by consuming milk from their mother. While distinct neural circuits underlying hunger and thirst drives in the adult brain have been characterized, it is unclear when these distinctions emerge in neonates and what processes may affect their development. Here we show that hypothalamic hunger and thirst regions already exhibit specific responses to starvation and dehydration well before a neonatal mouse can seek food and water separately. At this early age, hunger neurons drive feeding behaviors more than do thirst neurons. In vivo Neuropixels recordings in dehydrated and starved neonatal mice revealed that maternal presentation leads to a relative increase in activity which is suppressed by feeding on short timescales, particularly in hypothalamic and thalamic neurons. Changes in activity become more heterogeneous on longer timescales. Lastly, within neonatal regions that respond to both hunger and thirst, subpopulations of neurons respond distinctly to one or the other need. Combining food and water into a liquid diet throughout the animal's life does not alter the distinct representations of hunger and thirst in the adult brain. Thus, neural representations of hunger and thirst in mice become distinct before food- and water-seeking behaviors mature and are robust to environmental changes in food and water sources.Competing Interest StatementThe authors have declared no competing interest.Footnotes* Revised Figure 1 and 2, added Figure 3. Supplemental figures added accordingly. | |
| 653 | |a Hypothalamus | ||
| 653 | |a Food sources | ||
| 653 | |a Neonates | ||
| 653 | |a Dehydration | ||
| 653 | |a Environmental changes | ||
| 653 | |a Food | ||
| 653 | |a Maternal behavior | ||
| 653 | |a Feeding behavior | ||
| 653 | |a Hunger | ||
| 653 | |a Homeostasis | ||
| 653 | |a Food processing | ||
| 653 | |a Thirst | ||
| 653 | |a Neural networks | ||
| 653 | |a Thalamus | ||
| 700 | 1 | |a Wu, Yunming | |
| 700 | 1 | |a Mehaffey, Conor | |
| 700 | 1 | |a Espinoza-Campomanes, Leslie A | |
| 700 | 1 | |a Santos-Valencia, Fernando | |
| 700 | 1 | |a Franks, Kevin | |
| 700 | 1 | |a Luo, Liqun | |
| 773 | 0 | |t bioRxiv |g (Feb 13, 2025) | |
| 786 | 0 | |d ProQuest |t Biological Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3166351725/abstract/embedded/75I98GEZK8WCJMPQ?source=fedsrch |
| 856 | 4 | 0 | |3 Full text outside of ProQuest |u https://www.biorxiv.org/content/10.1101/2024.09.22.614378v2 |