MARC

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001 3168485565
003 UK-CbPIL
022 |a 0003-9888 
022 |a 1468-2044 
024 7 |a 10.1136/archdischild-2023-326625  |2 doi 
035 |a 3168485565 
045 2 |b d20250301  |b d20250331 
084 |a 270345  |2 nlm 
100 1 |a Akeju, Oluwasefunmi  |u Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK 
245 1 |a Changes to the UK childhood immunisation schedule 
260 |b BMJ Publishing Group LTD  |c Mar 2025 
513 |a Journal Article 
520 3 |a This article summarises the recommendations by the Joint Committee on Vaccination and Immunisation (JCVI) for a new UK childhood immunisation schedule following the discontinuation of the Hib/MenC vaccine by the manufacturer (currently used at 12 months of age as a booster for these antigens) and the rationale behind these changes to the schedule. From late 2025, when the current stock of Hib/Men C vaccine runs out, Men C vaccination will no longer be offered to toddlers, as the adolescent Men ACWY vaccination programme is expected to effectively sustain herd immunity. To improve herd immunity against polio and sustain Hib control by maintaining the current impact on Hib carriage in toddlers, an 18-month visit will be added to the vaccination schedule, where a booster dose of DTaP/IPV/Hib or DTaP/IPV/Hib/HepB will be offered. The second MMR (measles, mumps, rubella) dose will be advanced from 40 to 18 months to improve uptake, with a recommendation that both MMR doses are offered with varicella immunisation (MMRV (measles, mumps, rubella and varicella)), as addition of varicella to the schedule has been demonstrated to be cost-effective in recent modelling reviewed by JCVI. One of the recently licensed interventions for preventing respiratory syncytial virus (RSV) in infants (a maternal bivalent RSV prefusion F protein vaccine) will be incorporated into the new schedule, which should significantly reduce RSV burden in infants. In addition, higher-valency pneumococcal vaccines with wider serotype coverage may be introduced. 
651 4 |a United Kingdom--UK 
651 4 |a England 
653 |a Severe combined immunodeficiency 
653 |a Hepatitis B 
653 |a mRNA vaccines 
653 |a Gastroenteritis 
653 |a Mumps 
653 |a Severe acute respiratory syndrome coronavirus 2 
653 |a Rubella 
653 |a Respiratory syncytial virus 
653 |a Children 
653 |a COVID-19 
653 |a Human papillomavirus 
653 |a Outbreaks 
653 |a Sewage 
653 |a Influenza B 
653 |a Young adults 
653 |a Fatalities 
653 |a Disease transmission 
653 |a mRNA 
653 |a Infections 
653 |a Immunization 
653 |a Viruses 
653 |a Public health 
653 |a Streptococcus infections 
653 |a Teenagers 
653 |a Pandemics 
653 |a Rotavirus 
653 |a Vaccines 
653 |a Diphtheria 
653 |a Disease 
653 |a Measles 
653 |a Influenza 
653 |a Combined vaccines 
653 |a Risk groups 
653 |a Herd immunity 
653 |a Chicken pox 
653 |a Tetanus 
653 |a Immunity (Disease) 
653 |a Pertussis 
653 |a Age 
653 |a Epidemics 
653 |a Whooping cough 
653 |a Poliomyelitis 
653 |a Population decline 
653 |a Childhood 
653 |a Babies 
653 |a Cost Effectiveness 
653 |a Neurological Impairments 
653 |a Social 
653 |a Males 
653 |a Physical Disabilities 
653 |a Adolescents 
653 |a Immunization Programs 
653 |a Neonates 
653 |a Young Children 
653 |a Infants 
653 |a Toddlers 
653 |a Pregnancy 
700 1 |a Lees, Emily A  |u Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Fitzwilliam College, University of Cambridge, Cambridge, Cambridgeshire, UK 
700 1 |a Amirthalingam, Gayatri  |u UK Health Security Agency, London, UK 
700 1 |a Ramsay, Mary E  |u UK Health Security Agency, London, UK 
700 1 |a Pollard, Andrew J  |u Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; NIHR Biomedical Research Centre, University of Oxford, Oxford, UK 
773 0 |t Archives of Disease in Childhood  |g vol. 110, no. 3 (Mar 2025), p. 180 
786 0 |d ProQuest  |t Science Database 
856 4 1 |3 Citation/Abstract  |u https://www.proquest.com/docview/3168485565/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch 
856 4 0 |3 Full Text  |u https://www.proquest.com/docview/3168485565/fulltext/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch 
856 4 0 |3 Full Text - PDF  |u https://www.proquest.com/docview/3168485565/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch