Effective connectivity between the medial temporal lobes and early visual cortex modulated by unrestricted viewing predicts memory retrieval and gaze reinstatement
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| Vydáno v: | bioRxiv (Feb 20, 2025) |
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| Další autoři: | , |
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Cold Spring Harbor Laboratory Press
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| On-line přístup: | Citation/Abstract Full text outside of ProQuest |
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| 001 | 3168897747 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2692-8205 | ||
| 024 | 7 | |a 10.1101/2025.02.18.638908 |2 doi | |
| 035 | |a 3168897747 | ||
| 045 | 0 | |b d20250220 | |
| 100 | 1 | |a Ladyka-Wojcik, Natalia | |
| 245 | 1 | |a Effective connectivity between the medial temporal lobes and early visual cortex modulated by unrestricted viewing predicts memory retrieval and gaze reinstatement | |
| 260 | |b Cold Spring Harbor Laboratory Press |c Feb 20, 2025 | ||
| 513 | |a Working Paper | ||
| 520 | 3 | |a Memory and gaze behavior are intricately linked, guiding one another to extract information and create mental representations of our environment for subsequent retrieval. Recent findings from functional neuroimaging and computational modeling suggest that reciprocal interactions between the extended hippocampal system and visuo-oculomotor regions are functionally relevant for building these mental representations during visual exploration. Yet, evidence for the directionality of information flow during encoding within this reciprocal architecture in humans is limited. In the current study, we used dynamic causal modeling (DCM) to give a non-invasive account for the directional influences between these systems when new memories are created. Here, we provide novel evidence demonstrating how unrestricted, naturalistic visual exploration induces changes in this connectivity. Subsequent memory retrieval performance was also predicted by the pattern of connectivity modulated by unrestricted visual exploration, identifying the mechanism underlying a rich history of previous work linking increased gaze behavior during encoding to later memory. Together, these findings suggest that gaze behavior shapes the ways in which brain dynamics within and between the hippocampal system and early visual cortex unfold during encoding in humans. Importantly, these directional interactions support the building of coherent, lasting mental representations.Competing Interest StatementThe authors have declared no competing interest. | |
| 653 | |a Hippocampus | ||
| 653 | |a Memory | ||
| 653 | |a Exploration | ||
| 653 | |a Visual cortex | ||
| 653 | |a Information processing | ||
| 653 | |a Oculomotor behavior | ||
| 653 | |a Visual stimuli | ||
| 653 | |a Neuroimaging | ||
| 653 | |a Exploratory behavior | ||
| 653 | |a Information systems | ||
| 653 | |a Temporal lobe | ||
| 653 | |a Neural networks | ||
| 653 | |a Reinstatement | ||
| 700 | 1 | |a Zhong-Xu, Liu | |
| 700 | 1 | |a Ryan, Jennifer D | |
| 773 | 0 | |t bioRxiv |g (Feb 20, 2025) | |
| 786 | 0 | |d ProQuest |t Biological Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3168897747/abstract/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |
| 856 | 4 | 0 | |3 Full text outside of ProQuest |u https://www.biorxiv.org/content/10.1101/2025.02.18.638908v1 |