The Neuropeptide Sulfakinin, a peripheral regulator of insect behavior switch between mating and foraging
Guardat en:
| Publicat a: | bioRxiv (Feb 20, 2025) |
|---|---|
| Autor principal: | |
| Altres autors: | , , , , , , , |
| Publicat: |
Cold Spring Harbor Laboratory Press
|
| Matèries: | |
| Accés en línia: | Citation/Abstract Full Text - PDF Full text outside of ProQuest |
| Etiquetes: |
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|
MARC
| LEADER | 00000nab a2200000uu 4500 | ||
|---|---|---|---|
| 001 | 3168897853 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2692-8205 | ||
| 024 | 7 | |a 10.1101/2024.07.30.605941 |2 doi | |
| 035 | |a 3168897853 | ||
| 045 | 0 | |b d20250220 | |
| 100 | 1 | |a Hong-Fei, Li | |
| 245 | 1 | |a The Neuropeptide Sulfakinin, a peripheral regulator of insect behavior switch between mating and foraging | |
| 260 | |b Cold Spring Harbor Laboratory Press |c Feb 20, 2025 | ||
| 513 | |a Working Paper | ||
| 520 | 3 | |a Behavioral strategies for foraging and reproduction in the oriental fruit fly (Bactrocera dorsalis) are alternative options for resource allocation and are controlled by neuropeptides. Here we show that the behavioral switch between foraging and reproduction is associated with changes in antennal sensitivity. Starved flies became more sensitive to food odors while suppressing their response to opposite-sex pheromones. The gene encoding sulfakinin receptor 1 (SkR1) was significantly upregulated in the antennae of starved flies, so we tested the behavioral phenotypes of null mutants for the genes encoding the receptor (SkR1-/-) and its ligand sulfakinin (Sk-/-). In both knockout lines, the antennal responses shifted to mating mode even when flies were starved. This suggests that sulfakinin signaling via SkR1 promotes foraging while suppressing mating. Further analysis of the mutant flies revealed that sets of odorant receptor (OR) genes were differentially expressed. Functional characterization of the differentially expressed ORs suggested that sulfakinin directly suppresses the expression of ORs that respond to opposite-sex hormones while enhancing the expression of ORs that detect food volatiles. We conclude that sulfakinin signaling via SkR1, modulating OR expressions and leading to altered antenna sensitivities, is an important component in starvation-dependent behavioral change.Competing Interest StatementThe authors have declared no competing interest.Footnotes* We have made a revision. Some grammar and spelling errors had also been corrected. We removed the paragraph about the discussion regarding the evolution and ancestral function of CCK. | |
| 653 | |a Odorant receptors | ||
| 653 | |a Resource allocation | ||
| 653 | |a Mutants | ||
| 653 | |a Neuropeptides | ||
| 653 | |a Sex hormones | ||
| 653 | |a Phenotypes | ||
| 653 | |a Volatiles | ||
| 653 | |a Sulfakinin | ||
| 653 | |a Sex pheromone | ||
| 653 | |a Foraging behavior | ||
| 653 | |a Antennae | ||
| 653 | |a Mating behavior | ||
| 653 | |a Cholecystokinin | ||
| 653 | |a Bactrocera dorsalis | ||
| 700 | 1 | |a Bao Dong | |
| 700 | 1 | |a Yuan-Yuan, Peng | |
| 700 | 1 | |a Hao-Yue, Luo | |
| 700 | 1 | |a Xiao-Lan, Ou | |
| 700 | 1 | |a Zheng-Lin, Ren | |
| 700 | 1 | |a Park, Yoonseong | |
| 700 | 1 | |a Jin-Jun, Wang | |
| 700 | 1 | |a Jiang, Hongbo | |
| 773 | 0 | |t bioRxiv |g (Feb 20, 2025) | |
| 786 | 0 | |d ProQuest |t Biological Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3168897853/abstract/embedded/H09TXR3UUZB2ISDL?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3168897853/fulltextPDF/embedded/H09TXR3UUZB2ISDL?source=fedsrch |
| 856 | 4 | 0 | |3 Full text outside of ProQuest |u https://www.biorxiv.org/content/10.1101/2024.07.30.605941v3 |