Targeting TRPC-5 Channel Inhibition to Improve Penile Vascular Function in Erectile Dysfunction
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| Publicado en: | International Journal of Molecular Sciences vol. 26, no. 4 (2025), p. 1431 |
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| Otros Autores: | , , , , , , , , |
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MDPI AG
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| Acceso en línea: | Citation/Abstract Full Text + Graphics Full Text - PDF |
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| 003 | UK-CbPIL | ||
| 022 | |a 1661-6596 | ||
| 022 | |a 1422-0067 | ||
| 024 | 7 | |a 10.3390/ijms26041431 |2 doi | |
| 035 | |a 3171027142 | ||
| 045 | 2 | |b d20250215 |b d20250228 | |
| 084 | |a 231645 |2 nlm | ||
| 100 | 1 | |a Mariam El Assar |u Fundación para la Investigación Biomédica del Hospital de Getafe, 28905 Getafe, Spain; <email>patricia.sosa@iisgetafe.com</email>; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain; <email>leocadio.rodriguez@salud.madrid.org</email>; Instituto de Investigación IdiPaz, 28046 Madrid, Spain | |
| 245 | 1 | |a Targeting TRPC-5 Channel Inhibition to Improve Penile Vascular Function in Erectile Dysfunction | |
| 260 | |b MDPI AG |c 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Canonical transient receptor potential (TRPC) channels contribute to calcium homeostasis, which is involved in penile vascular contractility and erectile dysfunction (ED) pathophysiology. We evaluated the impact of TRPC5 inhibition on endothelial function in penile vascular tissue from aging rats and ED patients and its effect on the relaxant efficacy of PDE5 inhibitors. TRPC inhibitor-induced endothelial and neurogenic relaxations were evaluated in corpus cavernosum (RCC) from a rat model of aging-related ED and in human penile resistance arteries (HPRAs) and corpus cavernosum (HCC) from ED patients and organ donors (NoED). The TRPC5 inhibitor, AC1903, was more effective than TRPC3 and TRPC4 inhibitors in relaxing aged RCC and HCC and HPRA from ED patients. In addition to enhancing endothelial and neurogenic relaxations in RCC from aged animals, AC1903 improved endothelium-dependent relaxation in both HCC and HPRA from ED patients but not in tissues from NoED. Cavernosal expression of TRPC5 was not different between ED and NoED subjects. AC1903 potentiated relaxations to the PDE5 inhibitor, tadalafil, in HCC/HPRA from ED patients. TRPC5 inhibition improved penile vascular function in aged rats and patients with ED. TRPC5 inhibition could be a potential therapeutic target for ED, particularly when combined with PDE5 inhibitors to enhance treatment outcomes. | |
| 653 | |a Endothelium | ||
| 653 | |a Cardiovascular disease | ||
| 653 | |a Veins & arteries | ||
| 653 | |a Diabetes | ||
| 653 | |a Penis | ||
| 653 | |a Blood & organ donations | ||
| 653 | |a Aging | ||
| 653 | |a Pathophysiology | ||
| 653 | |a Erectile dysfunction | ||
| 653 | |a Smooth muscle | ||
| 700 | 1 | |a García-Gómez, Borja |u Department of Urology, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain; <email>gendine@hotmail.com</email> (B.G.-G.); <email>manuelalonsoisa@hotmail.com</email> (M.A.-I.) | |
| 700 | 1 | |a La Fuente, José M |u Serviço de Urologia, Centro Hospitalar e Universitário de Santo António (CHUdSA), 4099-001 Porto, Portugal; <email>lafuentecarvalho@gmail.com</email> | |
| 700 | 1 | |a Alonso-Isa, Manuel |u Department of Urology, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain; <email>gendine@hotmail.com</email> (B.G.-G.); <email>manuelalonsoisa@hotmail.com</email> (M.A.-I.) | |
| 700 | 1 | |a Martínez-Salamanca, Juan I |u Servicio de Urología, Hospital Universitario Puerta de Hierro, 28222 Majadahonda, Spain; <email>jims09@me.com</email> | |
| 700 | 1 | |a Fernández, Argentina |u Servicio de Histología-Investigación, Unidad de Investigación Traslacional en Cardiología—IRYCIS/UFV, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain; <email>argentina.fernandez@salud.madrid.org</email> | |
| 700 | 1 | |a Sosa, Patricia |u Fundación para la Investigación Biomédica del Hospital de Getafe, 28905 Getafe, Spain; <email>patricia.sosa@iisgetafe.com</email>; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain; <email>leocadio.rodriguez@salud.madrid.org</email>; Instituto de Investigación IdiPaz, 28046 Madrid, Spain | |
| 700 | 1 | |a Romero-Otero, Javier |u Servicio de Urología, Hospital Universitario HM Sanchinarro, HM Hospitales, 28050 Madrid, Spain; <email>jromerootero@hotmail.com</email> | |
| 700 | 1 | |a Rodríguez-Mañas, Leocadio |u Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain; <email>leocadio.rodriguez@salud.madrid.org</email>; Instituto de Investigación IdiPaz, 28046 Madrid, Spain; Servicio de Geriatría, Hospital Universitario de Getafe, 28905 Getafe, Spain | |
| 700 | 1 | |a Angulo, Javier |u Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain; <email>leocadio.rodriguez@salud.madrid.org</email>; Servicio de Histología-Investigación, Unidad de Investigación Traslacional en Cardiología—IRYCIS/UFV, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain; <email>argentina.fernandez@salud.madrid.org</email> | |
| 773 | 0 | |t International Journal of Molecular Sciences |g vol. 26, no. 4 (2025), p. 1431 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
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