Smart Dura: a functional artificial dura for multimodal neural recording and modulation
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| Veröffentlicht in: | bioRxiv (Mar 2, 2025) |
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Cold Spring Harbor Laboratory Press
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| 001 | 3172859385 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2692-8205 | ||
| 024 | 7 | |a 10.1101/2025.02.26.640369 |2 doi | |
| 035 | |a 3172859385 | ||
| 045 | 0 | |b d20250302 | |
| 100 | 1 | |a Montalvo Vargo, Sergio I | |
| 245 | 1 | |a Smart Dura: a functional artificial dura for multimodal neural recording and modulation | |
| 260 | |b Cold Spring Harbor Laboratory Press |c Mar 2, 2025 | ||
| 513 | |a Working Paper | ||
| 520 | 3 | |a A multi-modal neural interface capable of long-term recording and stimulation is essential for advancing brain monitoring and developing targeted therapeutics. Among the traditional electrophysiological methods, micro-electrocorticography (μECoG) is appealing for chronic applications because it provides a good compromise between invasiveness and high-resolution neural recording. When combining μECoG with optical technologies, such as calcium imaging and optogenetics, this multi-modal approach enables the simultaneous collection of neural activity from individual neurons and the ability to perform cell-specific manipulation. While previous efforts have focused on multi-modal interfaces for small animal models, scaling these technologies to larger brains, of primates, remains challenging. In this paper, we present a multi-modal neural interface, named Smart Dura, a functional version of the commonly used artificial dura with integrated electrophysiological electrodes for large cortical area coverage for the NHP brain. The Smart Dura is fabricated using a novel thin-film microfabrication process to monolithically integrate a micron-scale electrode array into a soft, flexible, and transparent substrate with high-density electrodes (up to 256 electrodes) while providing matched mechanical compliance with the native tissue and achieving high optical transparency (exceeding 97%). Our in vivo experiments demonstrate electrophysiological recording capabilities combined with neuromodulation, as well as optical transparency via multiphoton imaging. This work paves the way toward a chronic neural interface that can provide large-scale, bidirectional interfacing for multimodal and closed-loop neuromodulation capabilities to study cortical brain activity in non-human primates, with the potential for translation to humans.Competing Interest StatementThe authors have declared no competing interest. | |
| 653 | |a Optics | ||
| 653 | |a Electrodes | ||
| 653 | |a Electrophysiological recording | ||
| 653 | |a Brain | ||
| 653 | |a Calcium imaging | ||
| 653 | |a Implants | ||
| 653 | |a Computer applications | ||
| 653 | |a Neuromodulation | ||
| 653 | |a Information processing | ||
| 653 | |a Animal models | ||
| 653 | |a Neuroimaging | ||
| 653 | |a Genetics | ||
| 653 | |a Interfaces | ||
| 653 | |a Invasiveness | ||
| 700 | 1 | |a Hong, Nari | |
| 700 | 1 | |a Belloir, Tiphaine | |
| 700 | 1 | |a Stanis, Noah | |
| 700 | 1 | |a Zhou, Jasmine | |
| 700 | 1 | |a Karam Khateeb | |
| 700 | 1 | |a Hatanaka, Gaku | |
| 700 | 1 | |a Zabir Ahmed | |
| 700 | 1 | |a Ibrahim Kimukin | |
| 700 | 1 | |a Griggs, Devon J | |
| 700 | 1 | |a Bair, Wyeth | |
| 700 | 1 | |a Yazdan-Shahmorad, Azadeh | |
| 700 | 1 | |a Chamanzar, Maysamreza | |
| 773 | 0 | |t bioRxiv |g (Mar 2, 2025) | |
| 786 | 0 | |d ProQuest |t Biological Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3172859385/abstract/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3172859385/fulltextPDF/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |
| 856 | 4 | 0 | |3 Full text outside of ProQuest |u https://www.biorxiv.org/content/10.1101/2025.02.26.640369v1 |