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Isolation of vanA-Mediated Vancomycin-Resistant Enterococcus faecalis (ST1912/CC116) and Enterococcus faecium (ST80/CC17), optrA-Positive Linezolid-Resistant E. faecalis (ST32, ST1902) from Human Clinical Specimens in Bangladesh

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Publicado en:Antibiotics vol. 14, no. 3 (2025), p. 261
Autor principal: Sangjukta Roy
Otros Autores: Meiji Soe Aung, Paul, Shyamal Kumar, Md Nazmul Alam Khan, Nasreen, Syeda Anjuman, Muhammad Saiful Hasan, Haque, Nazia, Barman, Tridip Kanti, Khanam, Jobyda, Fardousi Akter Sathi, Shashwata, Paul, Mohammad Ibrahim Ali, Kobayashi, Nobumichi
Publicado:
MDPI AG
Materias:
Bangladesh
India
Clinical isolates
Urogenital system
Antibiotic resistance
Pathogens
Sequence analysis
Virulence factors
Nosocomial infection
Infectious diseases
Erythromycin
Antimicrobial resistance
Vancomycin
Antibiotics
Penicillin
Genes
Virulence
Levofloxacin
Drug resistance
Gentamicin
Plasmids
Nosocomial infections
Antimicrobial agents
High resistance
Linezolid
Streptococcus infections
Multilocus sequence typing
Enzymes
Enterococcus
Acceso en línea:Citation/Abstract
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Resumen:Background/Objectives: Enterococcus is one of the major nosocomial pathogens. The present status of antimicrobial resistance determinants and virulence factors was analyzed for current Enterococcus causing infectious diseases in Bangladesh. Methods: Clinical isolates of Enterococcus recovered from various specimens in a tertiary care hospital were analyzed. Antimicrobial susceptibility was measured by a broth microdilution test, and resistance genes/virulence factors were detected by uniplex/multiplex PCR, along with sequencing analysis as required. The sequence type (ST) of E. faecalis and E. faecium was identified based on a multilocus sequence typing (MLST) scheme. Results: For a one-year period, a total of 143 isolates (135 E. faecalis, 7 E. faecium, and 1 E. hirae) were collected. Although all E. faecalis isolates were susceptible to penicillin, high resistance rates were noted against erythromycin (87%) and levofloxacin (62%). High-level resistance to gentamicin was detected in 30% of E. faecalis and 86% of E. faecium. Vancomycin resistance due to vanA was identified in one isolate each of E. faecalis (ST1912, CC116) and E. faecium (ST80, CC17). Three E. faecalis isolates (2.2%) with ST32 or ST1902 were resistant to linezolid, harboring optrA-fexA. Conclusions: The present study identifies the vancomycin-resistant Enterococcus harboring vanA from humans in Bangladesh and shows the potential spread of optrA in multiple lineages of E. faecalis.
ISSN:2079-6382
DOI:10.3390/antibiotics14030261
Fuente:Biological Science Database