Optimal dose and type of exercise to improve motor symptoms in adults with Parkinson's disease: A network meta-analysis
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| Publicat a: | Journal of Science and Medicine in Sport vol. 28, no. 4 (Apr 2025), p. 282 |
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| Autor principal: | |
| Altres autors: | , , , , , , , |
| Publicat: |
Elsevier Limited
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| Matèries: | |
| Accés en línia: | Citation/Abstract Full Text Full Text - PDF |
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| Resum: | Objectives This study aimed to evaluate the dose-response relationship between different exercise types and the alleviation of motor symptoms in Parkinson’s Disease patients. Design A systematic review and network meta-analysis were conducted to compare the effects of 12 exercise types on motor symptoms in Parkinson’s Disease patients using randomized controlled trials. Methods A systematic search was conducted across PubMed, Medline, Embase, PsycINFO, Cochrane Library, and Web of Science until September 10, 2024. A total of 81 trials involving 4596 patients were included. Mean differences with 95 % credible intervals were calculated, and evidence quality was assessed using Confidence in Network Meta-Analysis. The Minimum Clinically Important Difference was used to assess clinical efficacy. Results The optimal exercise dose for overall motor symptom improvement was 1300 MET-min/week (mean difference: − <ce:hsp sp="0.10" />6.07, 95 % credible intervals: − <ce:hsp sp="0.10" />8.10 to − <ce:hsp sp="0.10" />4.01). Dance at 850 MET-min/week provided the greatest improvement (mean difference: − <ce:hsp sp="0.10" />11.18, 95 % credible intervals: − <ce:hsp sp="0.10" />16.01 to − <ce:hsp sp="0.10" />6.22). Significant improvements were seen with doses as low as 60–100 MET-min/week for body weight support training, dance, resistance training, and sensory exercise. The Minimum Clinically Important Difference was achieved with doses exceeding 670 MET-min/week for overall exercise, and at lower doses for specific types: aerobic exercise (1100 MET-min/week), body weight support (420 MET-min/week), and dance (230 MET-min/week). Conclusions The optimal exercise dose for alleviating motor symptoms in Parkinson’s Disease patients is 1300 MET-min/week, with dance being most effective at 850 MET-min/week. These findings provide evidence-based recommendations for Parkinson’s Disease management. |
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| ISSN: | 1440-2440 1878-1861 |
| DOI: | 10.1016/j.jsams.2025.01.003 |
| Font: | Health & Medical Collection |