Longitudinal high-density cortical auditory event-related potentials and speech-sound discrimination in the first two years of life in extremely and very preterm infants without developmental disorders

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Publicado en:NeuroImage vol. 310 (Apr 15, 2025)
Autor principal: Pelc, Karine
Otros Autores: Gajewska, Aleksandra, Napiórkowski, Natan, Dan, Jonathan, Verhoeven, Caroline, Bernard, Dan
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Elsevier Limited
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Acceso en línea:Citation/Abstract
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024 7 |a 10.1016/j.neuroimage.2025.121115  |2 doi 
035 |a 3186750658 
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100 1 |a Pelc, Karine  |u Université libre de Bruxelles (ULB), Facuty of Motor Sciences, Brussels, Belgium; Inkendaal Rehabilitation Hospital, Vlezenbeek, Belgium 
245 1 |a Longitudinal high-density cortical auditory event-related potentials and speech-sound discrimination in the first two years of life in extremely and very preterm infants without developmental disorders 
260 |b Elsevier Limited  |c Apr 15, 2025 
513 |a Journal Article 
520 3 |a Maturation of the auditory system in early childhood significantly influences the development of language-related perceptual and cognitive abilities. This study aims to provide insights into the neurophysiological changes underlying auditory processing and speech-sound discrimination in the first two years of life. We conducted a study using high-density electroencephalography (EEG) to longitudinally record cortical auditory event-related potentials (CAEP) in response to synthesized syllable sounds with pitch/duration change in a cohort of 79 extremely and very preterm-born infants without developmental disorders. EEG were recorded at 6 timepoints from term to 24 months corrected age, using a pseudorandom oddball paradigm. We found that the infant-P1 component of CAEP showed decreasing latency with age and more focalized cortical source stabilizing in the left primary auditory cortex by 6 months. By 6 months, a negative infant-N1 component emerged, its amplitude increasing with age and source localization showing increasing distribution over the left temporal, parietal and frontal lobes. Mismatch responses demonstrated significant differences in auditory discrimination capabilities starting from 6 months, indicating the infants' ability to detect phonetic differences. There was no correlation between infant-P1 latency, infant-P1 amplitude or mismatch response at term age and gestational age. This study suggests that cortical sound detection occurs very early and is not significantly influenced by the extent of prematurity but rather by corrected age. Early sound detection is followed by cortical sound content processing from about 6 months, with gradual organization along the cortical auditory dorsal stream and mirror neuron system in the first two years of life. Auditory discrimination of speech sounds also significantly changes from around 6 months of age. 
653 |a Gender differences 
653 |a Event-related potentials 
653 |a Auditory discrimination 
653 |a Phonetics 
653 |a Infants 
653 |a Localization 
653 |a Premature babies 
653 |a Age 
653 |a Auditory processing 
653 |a Speech 
653 |a Cortex (auditory) 
653 |a Developmental disabilities 
653 |a Electroencephalography 
653 |a Cognitive ability 
653 |a Amplitude (Acoustics) 
653 |a Longitudinal studies 
653 |a Sound 
653 |a Native languages 
653 |a Fetuses 
653 |a Auditory system 
653 |a Children 
653 |a EEG 
653 |a Frequency 
653 |a Age differences 
653 |a Temporal lobe 
653 |a Gestational age 
653 |a Speech sounds 
653 |a Premature birth 
653 |a Hearing 
653 |a Information processing 
653 |a Latency 
653 |a Newborn babies 
653 |a Speech perception 
653 |a Childhood 
653 |a Developmental disorders 
653 |a Density 
653 |a Life 
653 |a Discrimination 
653 |a Frontal lobes 
653 |a Changes 
653 |a Cortex 
653 |a Maturation 
653 |a Child development 
653 |a Disorders 
700 1 |a Gajewska, Aleksandra  |u Poland 
700 1 |a Napiórkowski, Natan  |u Poland 
700 1 |a Dan, Jonathan  |u École Polytechnique Fédérale de Lausanne (EPFL), Embedded Systems Laboratory, Lausanne, Switzerland 
700 1 |a Verhoeven, Caroline  |u Université libre de Bruxelles (ULB), Facuty of Motor Sciences, Brussels, Belgium; Université libre de Bruxelles (ULB), Faculty of Medicine, Department of Mathematics Education, Brussels, Belgium 
700 1 |a Bernard, Dan  |u Inkendaal Rehabilitation Hospital, Vlezenbeek, Belgium; Université libre de Bruxelles (ULB), Faculty of Psychology, Educational Sciences and Speech and Language Therapy, Brussels, Belgium 
773 0 |t NeuroImage  |g vol. 310 (Apr 15, 2025) 
786 0 |d ProQuest  |t Health & Medical Collection 
856 4 1 |3 Citation/Abstract  |u https://www.proquest.com/docview/3186750658/abstract/embedded/H09TXR3UUZB2ISDL?source=fedsrch 
856 4 0 |3 Full Text  |u https://www.proquest.com/docview/3186750658/fulltext/embedded/H09TXR3UUZB2ISDL?source=fedsrch 
856 4 0 |3 Full Text - PDF  |u https://www.proquest.com/docview/3186750658/fulltextPDF/embedded/H09TXR3UUZB2ISDL?source=fedsrch