Vitamin D for primary dysmenorrhea and endometriosis-related pain – A systematic review of registered RCTs

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Dades bibliogràfiques
Publicat a:	PLoS One vol. 20, no. 4 (Apr 2025), p. e0321393
Autor principal:	Zhou, Iris Wenyu
Altres autors:	Anthony Lin Zhang, Tsang, Miranda Sin-Man, Xue, Charlie C
Publicat:	Public Library of Science
Matèries:	Clinical trials Dietary supplements Vitamin deficiency Womens health Bias Endometriosis Menstruation Calciferol Vitamin D Intervention Uterus Chronic illnesses Nonsteroidal anti-inflammatory drugs Pain Inflammation Systematic review Social
Accés en línia:	Citation/Abstract Full Text Full Text - PDF
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Resum:	ObjectiveThis systematic review investigates the potential role of vitamin D supplement in alleviating pain associated with primary dysmenorrhea or endometriosis by analysing registered randomised controlled trials (RCTs).MethodsWe comprehensively searched the WHO International Clinical Trials Registry Platform to identify registered RCTs that assessed the effects of vitamin D supplement on pain outcomes in people with primary dysmenorrhea or endometriosis. The primary outcomes of interest were pain severity/intensity, pain duration, pain medication usage and pain-related outcome measurements.ResultsSeven registered RCTs were included in this systematic review. These RCTs had diverse doses and treatment durations of vitamin D supplement used as intervention. They also had either high or some concerns of risk of bias, according to Cochrane risk of bias version 2 assessment. Substantial heterogeneities were generally observed across the seven RCTs. When measured using a validated tool visual analogue scale (VAS), pain severity was significantly lower at the end of treatment when compared with placebo (mean difference MD –1.12, 95% confidence interval [–2.16, –0.07], I2=81%, 5 studies, n = 308). This significant difference was observed in the primary dysmenorrhea RCTs, but not the endometriosis RCTs.ConclusionThis systematic review identified vitamin D may reduce pain associated with primary dysmenorrhea, though a low certainty of evidence was available. Future studies that use standardised doses and treatment duration in accordance with the latest clinical practice guidelines are needed to explore any potential benefits vitamin D may have for people with these conditions.
ISSN:	1932-6203
DOI:	10.1371/journal.pone.0321393
Font:	Health & Medical Collection