Omslagsbillede

A double network composite hydrogel with enhanced transdermal delivery by ultrasound for endometrial injury repair and fertility recovery

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Udgivet i:Bioactive Materials vol. 50 (2025), p. 273
Hovedforfatter: Zhang, Xin
Andre forfattere: Wang, Shufang, Wang, Siyu, Long, Zeyi, Lu, Cong, Wang, Jianlin, Yang, Lijun, Yao, Cancan, He, Bin, Chen, Xihua, Zhuang, Taifeng, Xu, Xiangbo, Zheng, Yufeng
Udgivet:
KeAi Publishing Communications Ltd
Fag:
Biocompatibility
Cavitation
Zinc
Ultrasonic processing
Controlled release
Cell proliferation
Females
Traditional Chinese medicine
Hydrogels
Extracellular matrix
Adhesion
Cell migration
Endometrium
Antioxidants
Infertility
Biodegradability
Skin
Crosslinking
Transdermal medication
Sustained release
Injuries
Reproductive health
Efficiency
Fertility
Viscosity
Collagen
Fourier transforms
Rheology
Regeneration (physiology)
Ultrasound
Drug delivery
Viscoelasticity
Cell growth
Fibrosis
Ultrasonic imaging
Barriers
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Resumen:Endometrial injury and resulting female infertility pose significant clinical challenges due to the notable shortcomings of traditional treatments. Herein, we proposed a double network composite hydrogel, CSMA-RC-Zn-PNS, which forms a physical barrier on damaged tissue through photo-crosslinking while enabling sustained release of the active ingredient PNS. Based on this, we developed a combined strategy to enhance transdermal delivery efficiency using ultrasound cavitation. In vitro experiments demonstrated that CSMA-RC-Zn-PNS exhibits excellent biosafety, biodegradability, and promotes cell proliferation, migration, and tube formation, along with antioxidant and antibacterial properties. In a rat endometrial injury model, the ultrasound cavitation effect was demonstrated to enhance transdermal delivery efficiency, and the ability of CSMA-RC-Zn-PNS to promote endometrial regeneration, anti-fibrosis and fertility restoration was verified. Overall, this strategy combining CSMA-RC-Zn-PNS hydrogel and ultrasound treatment shows promising applications in endometrial regeneration and female reproductive health.
ISSN:2097-1192
2452-199X
DOI:10.1016/j.bioactmat.2025.04.007
Fuente:Materials Science Database