Integrative Multi-Omics and Clinical Data Analysis for Predicting Recurrence and Survival in Uterine Cancer
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| Publicado en: | ProQuest Dissertations and Theses (2025) |
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ProQuest Dissertations & Theses
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| Acceso en línea: | Citation/Abstract Full Text - PDF |
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| Resumen: | The prediction of uterine cancer recurrence is very important for assisting women in reducing the cancer risks and also for the growing field of personalized medicine. The primary aim of this thesis is to investigate the integration of various omics data alongside clinical and therapeutic information to predict survival in uterine cancer. The combination is very important for understanding the risk factors, including clinical aspects, genetics, and the treatment schedule, in order to prescribe the appropriate way to reduce the risk of recurrence, make clinical interactions easier, and enhance personalized patient care. This study utilizes the publicly accessible TCGA dataset, which includes multiple types of omics data, including mRNA, DNA Methylation, and Copy Number Alterations, alongside clinical data such as patient demographics, treatment details, and surgical information. This study involves employing a modern Graph Attention Networks model for generating embeddings, which were subsequently input into an ensemble classifier comprising MLP, SVM, Random Forest, and XGBoost classifiers. The performance of various classifiers and the ensemble model is analyzed to demonstrate the efficiency of each model using metrics like accuracy, AUC score, F-1 score, precision, recall, sensitivity and specificity. This strategy yielded a significant improvement in the accuracy of predicting uterine cancer recurrence. |
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| ISBN: | 9798314812983 |
| Fuente: | ProQuest Dissertations & Theses Global |