Glucagon-like Peptide-2 Acts Partially Through Central GLP-2R and MC4R in Mobilizing Stored Lipids from the Intestine
Պահպանված է:
| Հրատարակված է: | Nutrients vol. 17, no. 9 (2025), p. 1416 |
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| Հիմնական հեղինակ: | |
| Այլ հեղինակներ: | , , |
| Հրապարակվել է: |
MDPI AG
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| Խորագրեր: | |
| Առցանց հասանելիություն: | Citation/Abstract Full Text + Graphics Full Text - PDF |
| Ցուցիչներ: |
Չկան պիտակներ, Եղեք առաջինը, ով նշում է այս գրառումը!
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| 022 | |a 2072-6643 | ||
| 024 | 7 | |a 10.3390/nu17091416 |2 doi | |
| 035 | |a 3203214626 | ||
| 045 | 2 | |b d20250101 |b d20251231 | |
| 084 | |a 231545 |2 nlm | ||
| 100 | 1 | |a Mukherjee Kundanika | |
| 245 | 1 | |a Glucagon-like Peptide-2 Acts Partially Through Central GLP-2R and MC4R in Mobilizing Stored Lipids from the Intestine | |
| 260 | |b MDPI AG |c 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Background: Glucagon-like peptide-2 (GLP-2) is a gut hormone secreted in response to nutrient intake and regulates lipid metabolism in the gut. The present study aims to elucidate the underlying mechanism of GLP-2 in stimulating gut lipid secretion in the fasted state by testing whether GLP-2 signals through the brain’s GLP-2 receptor and melanocortin 4 receptor (MC4R). Methods: Sprague-Dawley rats were implanted with a mesenteric lymph duct cannula for measuring gut lipid secretion and an intracerebroventricular cannula for infusion of a GLP-2R antagonist (GLP-2(11-33)), an MC4R antagonist (SHU9119), or saline as a control. The rat received a lipid infusion into the small intestine and a peritoneal injection of GLP-2 five hours later. Results: Brain administration of a GLP-2R antagonist or an MC4R antagonist attenuated the stimulatory effects of peripheral GLP-2 on lymph triglyceride output. These effects were associated with differential changes in the expression of key genes in jejunal endothelial cells, smooth muscle cells, and neuronal cells. Conclusions: These results support the involvement of central GLP-2R and MC4R in a neural pathway for GLP-2 to mobilize lipids stored in the gut during the post-absorptive state. | |
| 610 | 4 | |a University of Saskatchewan | |
| 651 | 4 | |a St Louis Missouri | |
| 651 | 4 | |a United States--US | |
| 653 | |a Software | ||
| 653 | |a Glucagon | ||
| 653 | |a Gene expression | ||
| 653 | |a Peptides | ||
| 653 | |a Lipids | ||
| 653 | |a Surgery | ||
| 653 | |a Animals | ||
| 653 | |a Catheters | ||
| 653 | |a Morphology | ||
| 653 | |a Laboratories | ||
| 700 | 1 | |a Khan Muhammad Saad Abdullah | |
| 700 | 1 | |a Howland, John G | |
| 700 | 1 | |a Xiao Changting | |
| 773 | 0 | |t Nutrients |g vol. 17, no. 9 (2025), p. 1416 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3203214626/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text + Graphics |u https://www.proquest.com/docview/3203214626/fulltextwithgraphics/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3203214626/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |