Harnessing advanced computational approaches to design novel antimicrobial peptides against intracellular bacterial infections
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| Publicado en: | Bioactive Materials vol. 50 (2025), p. 510 |
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| Autor principal: | |
| Otros Autores: | , , , , , , , |
| Publicado: |
KeAi Publishing Communications Ltd
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| Materias: | |
| Acceso en línea: | Citation/Abstract Full Text Full Text - PDF |
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| LEADER | 00000nab a2200000uu 4500 | ||
|---|---|---|---|
| 001 | 3205990884 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2097-1192 | ||
| 022 | |a 2452-199X | ||
| 024 | 7 | |a 10.1016/j.bioactmat.2025.04.016 |2 doi | |
| 035 | |a 3205990884 | ||
| 045 | 2 | |b d20250101 |b d20251231 | |
| 100 | 1 | |a Fang, Yanpeng |u Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410083, PR China | |
| 245 | 1 | |a Harnessing advanced computational approaches to design novel antimicrobial peptides against intracellular bacterial infections | |
| 260 | |b KeAi Publishing Communications Ltd |c 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Intracellular bacterial infections pose a significant challenge to current therapeutic strategies due to the limited penetration of antibiotics through host cell membranes. This study presents a novel computational framework for efficiently screening candidate peptides against these infections. The proposed strategy comprehensively evaluates the essential properties for the clinical application of candidate peptides, including antimicrobial activity, permeation efficiency, and biocompatibility, while also taking into account the speed and reliability of the screening process. A combination of multiple AI-based activity prediction models allows for a thorough assessment of sequences in the cell-penetrating peptides (CPPs) database and quickly identifies candidate peptides with target properties. On this basis, the CPP microscopic dynamics research system was constructed. Exploration of the mechanism of action at the atomic level provides strong support for the discovery of promising candidate peptides. Promising candidates are subsequently validated through in vitro and in vivo experiments. Finally, Crot-1 was rapidly identified from the CPPsite 2.0 database. Crot-1 effectively eradicated intracellular MRSA, demonstrating significantly greater efficacy than vancomycin. Moreover, it exhibited no apparent cytotoxicity to host cells, highlighting its potential for clinical application. This work offers a promising new avenue for developing novel antimicrobial materials to combat intracellular bacterial infections. | |
| 653 | |a Biocompatibility | ||
| 653 | |a Databases | ||
| 653 | |a Cytotoxicity | ||
| 653 | |a Pathogens | ||
| 653 | |a Datasets | ||
| 653 | |a Toxicity | ||
| 653 | |a Drug resistance | ||
| 653 | |a Bacteria | ||
| 653 | |a Staphylococcus infections | ||
| 653 | |a Drug development | ||
| 653 | |a Amino acids | ||
| 653 | |a Vancomycin | ||
| 653 | |a Computer applications | ||
| 653 | |a Peptides | ||
| 653 | |a Prediction models | ||
| 653 | |a Efficiency | ||
| 653 | |a Therapeutic applications | ||
| 653 | |a Membranes | ||
| 653 | |a Simulation | ||
| 653 | |a Artificial intelligence | ||
| 653 | |a Cell membranes | ||
| 653 | |a Antibiotics | ||
| 653 | |a Bacterial infections | ||
| 653 | |a Antimicrobial agents | ||
| 653 | |a Antimicrobial peptides | ||
| 653 | |a Intracellular | ||
| 653 | |a Tuberculosis | ||
| 653 | |a Antimicrobial activity | ||
| 700 | 1 | |a Fan, Duoyang |u Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410083, PR China | |
| 700 | 1 | |a Feng, Bin |u Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410083, PR China | |
| 700 | 1 | |a Zhu, Yingli |u Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410083, PR China | |
| 700 | 1 | |a Xie, Ruyan |u Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410083, PR China | |
| 700 | 1 | |a Tan, Xiaorong | |
| 700 | 1 | |a Liu, Qianhui | |
| 700 | 1 | |a Dong, Jie | |
| 700 | 1 | |a Zeng, Wenbin | |
| 773 | 0 | |t Bioactive Materials |g vol. 50 (2025), p. 510 | |
| 786 | 0 | |d ProQuest |t Materials Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3205990884/abstract/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text |u https://www.proquest.com/docview/3205990884/fulltext/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3205990884/fulltextPDF/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |