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A Randomized Controlled Trial Comparing Subcutaneous Preservation of Bone Flaps with Cryogenic Preservation of Bone Flaps for Cranioplasty in Cases of Traumatic Brain Injury

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Publicado en:Brain Sciences vol. 15, no. 5 (2025), p. 514
Autor principal: Rachith, Sridhar
Otros Autores: Kumar, Anil, Kumar Harendra, Khan Abdul Vakil, Hakeem Abdul, Kumar, Deepak, Kumar, Anurag, Anwer Majid
Publicado:
MDPI AG
Materias:
India
Enrollments
Infections
Edema
Patients
Cryopreservation
Synthetic products
Neurosurgery
Trauma
Mortality
Intervention
Bones
Surgical site infections
Ostomy
Clinical trials
Abdomen
Consciousness
Statistical analysis
Skin & tissue grafts
Skull
Traumatic brain injury
Intracranial pressure
Acceso en línea:Citation/Abstract
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Resumen:Background and objectives: Decompressive craniectomy (DC) is a surgical procedure, useful for relieving the intracranial pressure following trauma. Following reduction in cerebral oedema, the bone is placed back to cover the defect. During the interim period, the bone flap may be preserved using cryopreservation or in subcutaneous tissue. This leads to a need to determine the benefits and risks involved in preservation of bone flap in a subcutaneous pocket or conventional freezer following decompressive craniectomy in traumatic brain injury. Materials and methods: An open randomized controlled trial was conducted at a level one trauma centre from July 2023 to December 2024. Simple randomization was performed in order to allocate patients into the subcutaneous preservation group and the cryogenic preservation group. Patients underwent cranioplasty after 3 months and were followed up post-operatively for complications and Glasgow Outcome Scale assessment. Results: The study initially recruited a total of 158 patients, out of which 104 patients remained eligible for the final analysis. The patients with cryopreserved flaps were found to have a higher rate of surgical site infection (31.3%) as compared to those with subcutaneously preserved flaps (5.6%), with the differences being statistically significant (p < 0.001). Among the 87 patients who had a poorer Glasgow Outcome Scale (GOS) score before the intervention, 55 (63.2%) patients had at least some improvement in GOS over a period of one month. Conclusion: The use of subcutaneous preservation of bone is more beneficial in resource-limited settings as compared to conventional freezer storage.
ISSN:2076-3425
DOI:10.3390/brainsci15050514
Fuente:Biological Science Database